A Plant-Based Option to Treat Ulcerative Colitis

New data presented during Crohn’s and Colitis Congress 2023 in Denver suggest an herbal compound curcumin and QingDai outperformed placebo to induce clinical response and remission in patients with ulcerative colitis. - https://www.hcplive.com/view/plant-based-option-treat-ulcerative-colitis

Let us know how it works for you.

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CCinPA said...
This says the study was 10 patients

Researchers conducted a two-part trial in 59 patients with active UC. The second was a placebo-controlled trial conducted at two centers in Israel and Greece, in which 42 patients were randomly assigned 2:1 to receive enteric-coated Curcumin / QingDai (3 g/day) or placebo for 8 weeks. Patients who responded continued curcumin or placebo alone for an additional 8 weeks as maintenance.

CCinPA said...
3 reached remission.

The primary outcome of clinical and endoscopic or biomarker response was met during the induction phase, achieved in 43% patients vs. only 8% with placebo. Additionally, endoscopic improvement (75%) and clinical remission (50%) rates were statistically significantly better compared with placebo. These rates are notable for being achieved in a difficult-to-treat population, as half of the patients were biologic or immunomodulators failures. Taken together with the placebo-controlled trial results, this definitely paves the way toward incorporation of this botanical approach as an add-on strategy in patients with active UC,” he said. - https://www.healio.com/news/gastroenterology/20230120/curcuminqingdai-induces-remission-in-active-uc-paves-the-way-for-integration-in-care

Aussie -- keep us posted on how you are doing.

What mesalamine exactly that didnt work anymore?
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It probably didn't work, so to say, because you weren't on rectal mesalamine enemas (my suggestion rather than the suppositories) as well.

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I'm currently megadosing curcumin to see if it can induce remission. If it works, I'll post back.

I have gotten very into TCM the past year or so and have read a lot of great things about Qing Dai. I do not think I would take it without guidance from a TCM doctor but that is just me. After so many years of doing natural methods, it never amounted into anything positive for me so I am always hesitant now. I am curious if it can give you guys remission. You might try qigong along with it just for some gentle movement and balancing of your energy channels. I do it every morning!

Second week almost completed on Evinature. Definitely less frequent toilet stops. Managed a 5km run on the weekend without a stop for the first time in a year! (there was a time where I had to stop almost every km) Yesterday I went almost 24 hours without a toilet stop. Major milestone!! I have a colonoscopy coming up in April so it will be interesting to see the results from that.

I've had 3 x 4 weekly infusions so far - the first infusion was end of November. Entyvio + Mezavant (been on 4 tablets a day for a year) is the current medication. There hadn't been much of a change in symptoms until the week I started Evinature.

CCinPA said...
The problem with trying several things at the same time is that you won't know what is actually helping.

I've struggled with this so many times over the years. When in a flare I throw everything I can muster at it...when things calm down, it's difficult to know exactly what has worked. The scientific method be damned, I just want to get better!

For instance, I started Remicade almost a year ago. At around 29 weeks of no improvement I was ready to give up, as was my GI. Oddly, at the same time I developed pain that sent me to the ER. Its cause was never determined, but my GI suggested Prilosec should it happen again. It did happen again, I took a 14-day course of Prilosec, my pain disappeared, but as importantly, so did my flare, to the point where am I as "normal" as I can reasonably expect to be.

Remicade finally worked? Prilosec changed my PH so that mesalamine released more effectively? Environmental? I don't know, but I keep a pack of Prilosec around, and continue my Remicade.

To make matters even more muddy, I was on QD for around a month just prior to the aforementioned pain (hence the nexus to this thread). I stopped it when the pain started, just because I wasn't sure if it was at fault. But maybe it had something to do with my symptom improvement?

Just fyi — took me 5 days to test positive for covid after my husband tested positive. I had a sore throat so went to clinic and tested positive for flu. But they also gave me a pcr test and that came positive for covid. So it can take awhile — even though you have symptoms.

Aussie -- Sorry to hear about the Covid test. Hopefully it doesn't through your progress too far off and you can get back on track quickly.

artvark -- it took me a long time on Remicade before I reached complete remission. It worked pretty quickly to get me functional but then I would just stay at the same place with lingering symptoms. Took almost 2 years with dose/frequency changes before I was finally in complete remission.