methotrexate??????

I'm not on it - the use of methotrexate in UC is contraversial - it is useful in Crohn's however. There are ongoing studies being done to establish whether it is helpful in UC. The existing studies that showed little benefit unfortunately used quite a small dose of methotrexate orally - the studies that showed benefit in Crohn's generally used doses of 25mg a week by injection - so if it is to be used for UC this is the dose that should be given.

The other difficulty it interpreting the studies for UC is that in the past methotrexate was used where azathioprine had failed so it was being used in a very treatment resistant subgroup of patients.

Have you ever been put on tacrolimus as there is some quite good evidence that this can be helpful for resistant UC - I think this is one treatment that may be on the cards for me soon.

Hope this is helpful