hi there- while Remicade hasn't "stopped" working for me, per se, it's lost a LOT of it's effectiveness. I've had 4 infusions, & after the 3rd one I started to flare 3 weeks after I got the drug. So I went on cipro, & upped my Imuran dose. I held out 'til my 4th infusion, which was last week. And I wouldn't say I'm in remission now at all, I still have bad urgencies & anywhere from 6-10 bm's a day. I dunno.... Right now I'm at the "contemplating surgery" step... my GI doc recommended I go for this most recent dose of Remicade, & see how I responded to it. We both felt that my reaction would sort of indicate which direction I was going in, if the Remicade would work or not. But he also suggested I go for a surgery consult, so... He did mention Humira, we may try that. Although at this point it seems like I'm delaying the inevitable. I keep thinking though of how awesome those first infusions were! I felt great! I get infusions every 8 weeks, & have not yet scheduled another one. I don't know if I will- I'm going to see how long I get relief from the most recent dose, then go from there. If I start to flare again in like a week, I'll probably go back on steroids & call the surgeon. Sucks.