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Regular Member

Date Joined Oct 2006
Total Posts : 148
   Posted 8/25/2007 11:42 PM (GMT -6)   
I've recently started Imuran after discovering that Pred. is probably the worst thing that I could ever take-- Meaning that I end up with the chills, a headache, and I vomit like crazy when I take as small as 10mg; I ended up in misery three different times going from 40mg to 20mg to 10mg... it was awful. It's terrible and my doctor has said that it's uncommon that someone react that way.. anyhow.
He's put me on Imuran and honestly, I really was scared to take it thinking that I may react the same way as I did with the Pred. Though, I took it and no issues thus far (I'm very excited about this). My doctor said that it takes about two to three moths to start taking action, I was just wondering has anyone who is on this medication noticed if works sooner than that? I'm going to the bathroom about 15 times a day now and I think that in three months, there's not going to be much of me left...

Post Edited (Kanditron) : 8/25/2007 10:47:12 PM (GMT-6)

Regular Member

Date Joined Jun 2007
Total Posts : 67
   Posted 8/26/2007 5:28 AM (GMT -6)   
I've heard the same thing, that it takes time to work. I'm sorry that the prednisone does not work well for you.
I sure know what it's like to be in the bathroom that much.....have recently started to feel so much better and hope that I can stay like this for a bit.
Maybe your doctor could give you some enemas to help for a bit, like Cortenemas? Have you tried that? You're right after three'll be wiped out! I hope you feel better soon!
UC diagnosed in 1985...22 years.
4th Remicade infusion due on Sept 25th

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 8/26/2007 7:39 AM (GMT -6)   
You may get as lucky as I as and notice a difference in 7 weeks. Though I personally think that either 6mp or Imuran will affect any inflammation faster if the flare is mild/moderate than if the flare is severe. With a severe flare, it only stands to reason that it would take longer to heal. I will keep my fingers crossed for you that it will work quickly!

Left sided Uc since '92 - meds - Colazal, Canasa (when needed), 6MP (50-75mgs), Forvia, Biotin (IN REMISSION - sort of!)
Secondary Raynauds Syndrome '04  - meds - Norvasc
Fibromyalgia '06 - no meds
Severe seasonal allergies - meds - Allegra 
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@


Regular Member

Date Joined Jul 2007
Total Posts : 208
   Posted 8/26/2007 11:15 AM (GMT -6)   
It took three months for Imuran to kick in for me. I still had a flare-up four-five months after it seemed like it was working. :( But everyone is different. I hope it starts to work for you soon.
Ash 39 NH, vegetarian
Diagnosed with UC July 06 (I think 6/6/6) during 10 day hospitalization
Current meds: Asacol 12, Imuran 150mg
Centrum Silver, VSL #3, olive leaf extract, DHA-Omega 3, L-glutamine

Regular Member

Date Joined Oct 2006
Total Posts : 148
   Posted 8/26/2007 11:30 AM (GMT -6)   
That's sooooo long.

My doctor has never suggested enemas for me and I'm guessing that it's probably because I have pancolitis. I'm not sure, but he has never said a word about it. I suppose I could just ask.
25 years old
Diagnosed 9/06 with Pancolitis
Asacol 3 3x's a day... not any more
Colazal 3 3x's a day
Can not tolerate Prednisone in the slightest amount
Imuran 100mg a day. Which I started 8/24.

Veteran Member

Date Joined May 2007
Total Posts : 528
   Posted 8/29/2007 7:43 PM (GMT -6)   
actually, I respectfully disagree with BillShakespeare, at least to a degree. he is right that your GI shoudl have considered enemas, however, as someone with pancolitis, I haven't had any luck using enemas. my GI said to keep the ones he originally prescribed for me because they are so expensive and may come in handy later, but because they can't reach very far up the colon, they are not nearly as effective in pancolitis. you probably should try them, but my (potentially disenchanted) opinion is that they probably won't work. But, you never know....
Pancolitis dx 3/07.
Currently on 12 Asacol a day.
*100mg Imuran b/c steroid dependent.
*back on prednisone while Imuran kicks in. Down to 5 mg on 8/13.
Various vitamins, probiotics, fish oil.
Engaged: June 1, 2007

Another UC wife
Veteran Member

Date Joined Jun 2007
Total Posts : 2111
   Posted 8/29/2007 10:34 PM (GMT -6)   
Hi There - my husband started the Imuran along with prednisone to help it "kick in" (I realize you can't tolerate the prednisone)

That was 3 1/2 months ago - and we are tapering the prednisone - it is helping and working but he is not in a true remission as he still needs pain meds to be functional. I understand it can take 3-6 months to work.

However the advice of a few on this board about the rectal meds.....we started them on June 26th and on July 2nd there was a noticeable improvement. The improvement was such that he went from a total recluse with uncontrollable urges and living in the bathroom and bed to being able to go out for a few hours and socialize which was a major thing. We would be careful about food before going out - made sure he ate first - spent some time in the house and use the bathroom before going out. While out and needing to eat making sure it was smaller amounts and not be too far from home.

My husband uses Colocourt. There are others out there and the doctor should know which would be best to prescribe for you. Hopefully you can retain it for at least 2 hrs before having to dispel it or part of it as most of the medicine would be absorbed. My husband had a problem holding them for many hours but after 2 - 3 hours due to gas primarily he would go to the bathroom but there was very little coming out as it was only the gas so he was absorbing most of the medicine. Maybe they will provide some additional help and comfort for you until the imuran takes a better hold. Hopefully it won't be too long for you.

60 yr old male~Colitis 1st diagnosed Jan '05-cleared up within a few wks. Flared again in May '06 ... left sided UC now, fully involved and trying to get in remission. Acute inflammation-pancolitis-tenesmus rectal pain-granulation is showing some healing started. Osteopena of spine from prednisone DX 8/07  July 07 good days & bad days 75mg Imuran 40  mg prednisone (tapering 8/07) 12 Asacol, Lidocaine Hydrochloride Jelly 2%,multi vitamin, iron 3X day, DanActive, chewable calcium, Prilosec 20mg, enalapril 10mg, glipizide 5 mg, zocor 20 mg, baby aspirin, (Fentanyl pain patch 50mg 72 hrs  Morphine Sulf 15 mg twice daily)Colocourt enemas at night. Fosamax and mthly B12 shots folic acid 1mg

Regular Member

Date Joined Jun 2004
Total Posts : 123
   Posted 8/30/2007 5:54 AM (GMT -6)   
I started Imuran in February as I was tapering off of Pred. My last Pred dose was in May (after 50 weeks!).
I don't notice anything begin on Imuran. And, that's a good thing.
I want to continue to feel good and not see another flare for many, many years - decades even!
I go for my regular blood tests once a month (after I started weekly, then bi-weekly, then moving to monthly) and I hope to see continued success!

February 04: Rushed to hospital with severe blood haemorrhage. Diagnosed with indeterminate UC in 2/3 of my bowel. Treated with heavy doses of Pred; started Salofalk tabs and sups.


April 06: First major flare – more haemorrhaging. Colonoscopy once against confirmed indeterminate UC.


May 06: Started 40 mg Pred. Weaned down to 10mg by July 8, held at 10mg until December 20, tapering 1mg every 2 weeks, 5mg a day as of February 14. All this plus 10 Salofalk tabs daily.


Jan through May 2007: Suffering from severe headaches and vomiting likely caused by prednisone.


Feb 26 07: Started Imuran with continued success.


May 12 07: Final dose of prednisone after 50 weeks!

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