Good timing or awesome med?

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New Member

Date Joined Jul 2007
Total Posts : 14
   Posted 8/26/2007 7:23 PM (GMT -6)   
I was taking a high dosage of Prednisone for two weeks with absolutely no results then took just one day of Canasa (mesalamine, USP) 1000mg Rectal Suppositories and the flareup is GONE!!!!!!!!  I've been suffering with this current flare for 6 months now!  I've been taking two a day along with the other meds but can it be just good timing or are these just the right stuff?  So far it's been 5 days with a complete turn around.  Anyone else have success with Canasa? 
John - 38
Diagnosed to have UC in 1987
4800 MG of Asacol daily
2 Hydrocortisone Enimas
1500 MG Metronidazole
500 MG Levaquin

Deb McG
Regular Member

Date Joined May 2007
Total Posts : 33
   Posted 8/26/2007 7:28 PM (GMT -6)   

I've had help withe Canasa, but it didn't work that fast.  It's probably the combination of the two.  Mine took about 5 days before I noticed a big improvement.  But hey, if it's working, keep your fingers crossed that it will continue to help.  Good Luck.

Deb McG

UC - 20+ years
6 MP
Prednisone (UGH)
Folic Acid/Calcium/Magnesium

Elite Member

Date Joined May 2003
Total Posts : 30986
   Posted 8/26/2007 9:01 PM (GMT -6)   
Your flare won't disappear after one suppository. It could be that the pred has just kicked in and the rectal inflammation is being helped by the canasa...

or am I misreading your posting that you're still on pred?

What dosage are you on at this time?

You're as well on the asacol, metronidazole, steroid enemas (twice daily) AND now started the Canasa?

I'm puzzled why you would think that it was just the Canasa?
Although...I'm a huge 5ASA "fan"....but I wouldn't give it that much credit.

Would you clarify what exactly you're on.

it's great you're feeling better, haven't tapered pred yet.

*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 3rd night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Elite Member

Date Joined Feb 2004
Total Posts : 20577
   Posted 8/26/2007 11:46 PM (GMT -6)   
Chances are, if you were on a high dose of pred for 2 weeks, then you were/are still on the pred while taking the canasa and it's more then likely the pred kicked in for you...pred is a funny drug, it can kick in after one dose or take many doeses/weeks to kick in, or even not kick in at all.

Are you still on the pred? and at what dose were you on the first 2 weeks and are on now?

My bum is broken....there's a big crack down the middle of it!  LOL  :)

Old Hat
Veteran Member

Date Joined Feb 2007
Total Posts : 5190
   Posted 8/29/2007 9:10 AM (GMT -6)   
Glad to read that you're finally getting relief. Steroids have always acted quickly for me when I desperately needed them. How long have you been taking Metronidazole? This is a drug to beware of because it can cause peripheral neuropathy!!!!! My gastro said in a public forum last yr that IBD patients should not stay on it longer than 3 months max for that reason!!!!! Good luck with your treatment & best wishes for continued progress to remission. / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 X 3 Colazal daily for July flare in descending colon, which is responding)

Regular Member

Date Joined Jul 2007
Total Posts : 160
   Posted 8/29/2007 6:46 PM (GMT -6)   
I am getting the same results (relief after a 3+ mos. long flare) but with a different drug:  6-MP.  I've only been taking it for 2 weeks so I know it cannot possibly be giving me this relief alone - I don't think?  But I am also still on Prednisone (9 weeks and counting) so who knows.................I'm baffled, but pleasantly surprised!!
Best wishes for continued healing!
dx w/UC (pancolitis) March '06
Colazal 750 mg x 9 capsules daily
now on Prednisone, 20 mg. daily
started 6-MP 8/13/07 (50 mg. daily)
Probiotics (Primadophilus Reuteri)
dx w/Type 2 Diabetes Nov. 2002
Metformin 500 mg. x 2 daily,Caduet 5/10 mg. daily, Micardis 80 mg. daily, multivitamin + calcium daily and one baby aspirin, CinndromeX (4 daily)
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