Sulfasalazine and Rash

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Regular Member

Date Joined Jun 2007
Total Posts : 364
   Posted 8/29/2007 1:00 PM (GMT -6)   
My 8 year old daughter started sulfasalazine this past Saturday and last night we noticed a very fine/faint rash on her legs and arms. We stopped the sulfa and are waiting for the doctor to call back with further instructions.

Would this likely be from the "sulfa" part of the drug (I get a rash from "sulfa" drugs)? Will she likely be able to tolerate other 5ASA's? Can you share your experience?

My son has taken sulfasalazine for almost 5 years now with no trouble.


Mom to son 15 and daughter 8, both UC

Elite Member

Date Joined May 2003
Total Posts : 30984
   Posted 8/29/2007 1:06 PM (GMT -6)   
Hi...I don't understand why your kids are on a sulfa containing med rather than on the straight 5ASA anyway.

It could be the sulfa...but, it would be best for you to get the doc to switch to Asacol for your daughter if she has a rash. If they cause her the rash, it's definitely the salicylates that are the problem.

Keep us updated for sure.
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 3rd night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

potty girl
Veteran Member

Date Joined Dec 2006
Total Posts : 835
   Posted 8/29/2007 3:20 PM (GMT -6)   
Yes sulfa caused me to have a rash on my stomach but I take asacol with no problems at all

synthroid .088 mg, lowpressor 50 mg x 2, cozaar 25mg x2, imdur 30 mg
nitroquick, proventol, plavix 75 mg, protonix 40 mg x 2, asacal 400mg x 9
carafate 1 gm x 4, zyrtec 10 mg, rhinocort aqua nose spray, fish oil,

Veteran Member

Date Joined Dec 2005
Total Posts : 3238
   Posted 8/29/2007 3:42 PM (GMT -6)   
I'm allergic to sulfa and so it my dad (he doesn't have uc took something else containing sulfa). Anyway I had my first ever migraine on sulfasalazine. My dad broke out in a rash from head to toe. Did you call your pediatrician? They may suggest benadryl.

100mg Azathioprine, 2 Fibercon, Colazal-9 a day (attempting to cut this down to 6 by slowly tapering), acidopholis pearls, just added Prilosec OTC
Co-Moderator UC Forum

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 8/29/2007 9:10 PM (GMT -6)   
Sulfa sensitivity is pretty common actually. I get anywhere from hives, welts or major intestinal pain. Did the rash disappear or start to look better after you stopped the sulfasalazine?
Left sided Uc since '92 - meds - Colazal, Canasa (when needed), 6MP (50-75mgs), Forvia, Biotin (IN REMISSION - sort of!)
Secondary Raynauds Syndrome '04  - meds - Norvasc
Fibromyalgia '06 - no meds
Severe seasonal allergies - meds - Allegra 
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@


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