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Nuvion (therapy in trials) discontinued

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Ulcerative Colitis
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AKB
Veteran Member
Joined : Mar 2006
Posts : 992
Posted 8/29/2007 10:38 AM (GMT -8)
That's too bad... any new drug would be an additional weapon against colectomy.


Nuvion (visilizumab) Pivotal Program Termination

Following review of data communicated by the Nuvion DMC this past Friday, August 24, PDL has decided that it will no longer pursue its phase 3 program of visilizumab in IVSR-UC, including both the RESTORE 1 and RESTORE 2 studies. The DMC interim evaluation included data from 91 patients in the RESTORE 1 trial at the 45-day primary endpoint. The analysis showed insufficient efficacy and an inferior safety profile in the visilizumab arm compared to IV steroids alone. The company is currently reviewing whether to continue the ongoing dose-ranging trial while it thoroughly evaluates the broader implications of these very recent results to the overall visilizumab program.
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kb5
Veteran Member
Joined : Jan 2007
Posts : 1015
Posted 8/29/2007 1:59 PM (GMT -8)
I once did a trial for a drug that never came out. It was amazing. I was in a terrible flare and it was 80% clear in two weeks on this aloe based drug. I was on it for about two months and it was fantastic! Worked better than prednisone ever has and it will never be seen by the public.
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scooterk
Regular Member
Joined : Dec 2006
Posts : 124
Posted 8/29/2007 4:55 PM (GMT -8)
KB5: Did you ever follow up on that treatment on your own? I'm doing my own treatment (lidocaine enemas) based on somebody's dormant patent and it's working great--better than anything else I've tried. Can you give me the name of the trial drug and anything else you know about it? That would be cool. Thanks!
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