Should I give up hope - 14 weeks and no results

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porclein
New Member


Date Joined Aug 2007
Total Posts : 15
   Posted 9/11/2007 5:50 PM (GMT -7)   
Hi,
 
It has been 14 weeks, the last 5 of which I have been on 200 mg of imuran.  So far no positive results.  I went into a big flare when I went down to 10 mg of pred.  Should I  give up hope for the imuran?
 
For those on imuran, how long did it take before you noticed some positive effect??
 
Please respond.

Thanks,
 
porclein- diagnosed 1/05 with pancolitis -on and off pred. since. asocol and colazol - had too many side effects mostly fatigue. eyes

tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 9/11/2007 5:58 PM (GMT -7)   
I started it in April and I want to say it was Aug/Sept before I felt the full effects. I was on pred. at the same time as well ending in mid-August. What's your doc say? I'm sorry you are having a tough time.
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-6 a day, Acidopholis Pearls, Prilosec OTC

http://www.healingwell.com/donate
Co-Moderator UC Forum


porclein
New Member


Date Joined Aug 2007
Total Posts : 15
   Posted 9/11/2007 6:11 PM (GMT -7)   
My doc still has hope. But I really want this to work. I am starting a new job in two weeks and I need energy.

Were you ever on a higher dose that 100mg of aza.?

tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 9/11/2007 6:15 PM (GMT -7)   
I did get up to 150mg. I was on it a few weeks and my promethus tests and labs showed it was way too high of a dose so I cut back to 100mg. Has there been any talk of upping the pred until the imuran kicks in? How many colazal are you taking?
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-6 a day, Acidopholis Pearls, Prilosec OTC

http://www.healingwell.com/donate
Co-Moderator UC Forum


porclein
New Member


Date Joined Aug 2007
Total Posts : 15
   Posted 9/11/2007 6:48 PM (GMT -7)   
I am back on 25 mg. of pred. Colazol and asocal made me very very tired so I have not been on it for about one year. Maybe I will have to try it again.

So would you say you are in remission? Does the aza make you tired? Do you feel any side effects from it?

Another UC wife
Veteran Member


Date Joined Jun 2007
Total Posts : 2111
   Posted 9/11/2007 7:21 PM (GMT -7)   
Hi porclein -- my husband started on the aza mid May. He has improved somewhat but not in remission. He is on 75 mg and his recent prometheus test results pleased his GI and she is keeping him at the 75mg. We have an appt with the Mayo Clinic in Jacksonville soon and it will be interesting to see if they agree on the 75 mg dosage or not. Maybe a higher dose will help bring a remission sooner? I remember hearing it takes 3-6 months or maybe longer. He is currently tapering on the prednisone down from 40mg to 17 1/2 mg. Not sure what will happen when we get to 10 and lower as the really low doses and discontinuance is when he got into real problems but was not on the aza then. Plus he still needs the daily regimine of pain meds to allow him to be functional which concerns me. Without them he would be miserable and probably not get out of bed.

We helped to host a 60th party on Sunday - not a very good day for him - he was uncomfortable. In addition to the normal daily pain meds he needed additional pain meds in the afternoon and at night. Monday he woke up and had an unbelievable normal day all day and last night we had two couples over for cards. Almost no discomfort whatsoever...go figure. It was like a "normal" day when he never had UC and his mood and personality was top notch. (Our friends and myself really enjoyed seeing his "old self" back even if it was temporary.)

Today was just ok - had an eye appt - we had to do a few errands - but he had some discomfort and came home and rested the remainder of the day. I don't know how many are on this kind of see saw and it is somewhat discouraging. But you have to take each day as it comes....I hope they will get better for you soon.

Yes he is always tired and his energy level is so low. If your Dr hasn't had the prometheus test done yet maybe that will be a good idea to evaluate your dosage??

Good luck with the new job - hope it goes well for you.

60 yr old male~Colitis 1st diagnosed Jan '05-cleared up within a few wks. Flared again in May '06 ... left sided UC now, fully involved and trying to get in remission. Acute inflammation-pancolitis-tenesmus rectal pain-granulation is showing some healing started. Osteopena of spine from prednisone DX 8/07  July 07 good days & bad days 75mg Imuran 40  mg prednisone (tapering 8/07) 12 Asacol, Lidocaine Hydrochloride Jelly 2%,multi vitamin, iron 3X day, DanActive, chewable calcium, Prilosec 20mg, enalapril 10mg, glipizide 5 mg, zocor 20 mg, baby aspirin, (Fentanyl pain patch 50mg 72 hrs  Morphine Sulf 15 mg twice daily)Colocourt enemas at night. Fosamax and mthly B12 shots folic acid 1mg


Eric704
Regular Member


Date Joined Jan 2006
Total Posts : 261
   Posted 9/11/2007 11:40 PM (GMT -7)   
I was on it for 4 years. Didn't do anything.

MitzMN
Veteran Member


Date Joined Feb 2007
Total Posts : 622
   Posted 9/12/2007 7:00 AM (GMT -7)   
I've been on it for about five years. It's been a very good drug for me.

You do need to give it time. In the interim, maybe a bump in your pred, until it kicks in and starts working, is the best course.

Good luck!
Mitz
Sporadic proctitis since about 1985. Mother had UC, then J-pouch surgery 1983.
DX'd with clostridium difficile in 2000. Prednisone, two courses of Flagyl, then Vancomycin finally got rid of it. Symptomatic with UC after that.
Colonoscopy in 2001 dx'd left-sided UC. Was pretty darn ill at that time. Treated with prednisone, Rowasa, Asacol. Asacol not working so switched to Imuran. Three small flares since in 2002, 2005, and 2007.
Gall bladder attack 6/13; ultrasound showed stones; surgery before end of 2007.
100 mg Azathioprine and 225 mg Effexor XR (for chronic, longstanding depression) daily.

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