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Vitamin E enemas

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Posted 9/16/2007 5:59 PM (GMT -7)
Hi there

I am new to the forum. Does anyone have experience with vitamin E enemas for active flares of distal disease? How do they compare to the 5-ASA enemas?

C 

Posted 9/17/2007 12:02 AM (GMT -7)
Tried it for a couple weeks. Hard to mix, takes alot of patience and in the end.. wasn't worth it to me. Didn't help at all.. It was too time consuming to do on a daily basis.
Posted 9/17/2007 7:00 PM (GMT -7)
It would be interesting to know how many people actually have had benefit from Vitamin E enemas.

There are only very few official research studies (for obvious reasons) on this issue. However, there is some animal research showing benefit with vitamin E derivative enemas in the treatment of expiremental colitis in rats (see below). 

Please give me your comments and experiences. Do you think it works?

1: Int J Mol Med. 2006 Mar;17(3):497-502. <script language=javascript1.2><!-- var Menu16465398 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["Compound (MeSH Keyword)" , "window.top.location='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pccompound&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pccompound_mesh&LinkReadableName=Compound%20(MeSH%20Keyword)&IdsFromResult=16465398&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Substance (MeSH Keyword)" , "window.top.location='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pcsubstance&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pcsubstance_mesh&LinkReadableName=Substance%20(MeSH%20Keyword)&IdsFromResult=16465398&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["LinkOut", "window.top.location='http://www.ncbi.nlm.nih.gov/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=16465398&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""] ] --></script> Links

Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats.

<!--AuthorList-->Isozaki Y, Yoshida N, Kuroda M, Takagi T, Handa O, Kokura S, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T.

Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.

Lipid peroxidation mediated by oxygen free radicals plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Vitamin E is a lipid-soluble antioxidant and is generally considered to protect against lipid peroxidation of the cell membrane and to scavenge singlet oxygen and superoxide anion radical. Therefore, vitamin E or its derivatives are expected to have particular application for patients suffering from IBD. The aim of this study was to investigate the antioxidative effects of the water-soluble vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetra-methylchroman-6-ol(TMG), on the therapy of experimental colitis in rats. Colitis was induced in male Wistar rats weighing 200 g using an enema of trinitrobenzene sulfonic acid (TNBS) dissolved in 50% ethanol; TMG dissolved in physiological saline was injected intra-peritoneally every day from 24 h after the enema of TNBS. The damage score, wet weight of the colon, and increase in body weight were estimated 1 week after the enema of TNBS. Thiobarbituric acid-reactive substances (TBA-RS), an index of lipid peroxidation, and tissue-associated myeloperoxidase (MPO) activity in the colonic mucosa were measured 1 week after the induction of colitis. As a result, increase in body weight was inhibited by the induction of colitis, although the inhibition was reduced in the group treated with TMG. The damage score, wet weight, TBA-RS and MPO activity were increased significantly in the colitis group; however, they were inhibited by the administration of TMG. These results suggest that TMG is effective for the treatment of colitis in rats induced by TNBS. In the future, TMG could be a new therapeutic agent for IBD.

Posted 9/18/2007 7:16 PM (GMT -7)
Connor, 

I had my local compounding pharmacy create the vitamin e enema for me.  They used Sheldon's formula and said it was a lot of work poking the capsules so they searched to find a liquid vitamin e.  NOW Foods was where they found the liquid E.  I am not sure which one it is they ordered, but here is a sight where I found it.  I know they mixed it with distilled water and it was so more convient to have it made in sterile conditions. 

I did the vitamin E enema from February to April.  During this time I also changed my diet .  I eliminated pasta, breads, processed foods.  I ate a lot of crockpot chicken, fish, creamy Maranatha peanutbutter& Raw honey, asparagus, cooked carrots and spinach, Soymilk, StonyFields yogurt, eggs and cheese.  Everything organic if possible.  By the end of April I had formed stools, no diarhea, no mucous, very little cramping. 5 months later I only have a little blood in my stool in the morning.  

I have my bm in the morning after my shower.  That is the way my body has always been.  I don't have time to lay down to let the enema work it's way up my colon.  Sunday -Friday I am up by 5:45 a.m. and have to have myself and four kids out the door by 7a.m. It's hard enough getting up by 5:45  than to even think about getting up earlier.   So I may get to do the enema on Saturday.  I did find some vitamin E suppositories. 

I really think it has been a combination of the Vitamin E enema,  the diet, and the supplements.

My family dr  agreed to try  Asacol in July, only 3 pills a day and recently upped it to 2 pills 3 times a day.  I still have a slight amount of blood though. 

I hate taking a whole lot of prescription drugs. Plan on calling the GI doctor.  I dread calling the GI doc.  I don't want to take so many prescription pills.

I want to take the least amoung possible to heal the colon.  I know I need another colonoscopy, it's been a year now. 

Snookiebow

 

First flare:  August 2006, diagnosed September 2006-

Dipentum and Entocort September and October 2006- now trying Asacol
Garden Of Life:  Primal Defense, Digestive Enzyme, and FYI
Glutamine Caps, DHEA, , vitamin E, Capryl, Turmeric & Bromelain
Omega 3- Fish oil, Biotin, Cal-Gel
Vitamin E enema & occasional Rowasa enema
AloeVera juice

Posted 9/18/2007 7:22 PM (GMT -7)
http://www.nextag.com/now-vitamin-e-liquid/search-html

Here is a website for the NOW Foods vitamin E.
I'm not sure which bottle my pharamacist ordered.

Snookiebow
First flare:  August 2006, diagnosed September 2006-

Dipentum and Entocort September and October 2006- now trying Asacol
Garden Of Life:  Primal Defense, Digestive Enzyme, and FYI
Glutamine Caps, DHEA, , vitamin E, Capryl, Turmeric & Bromelain
Omega 3- Fish oil, Biotin, Cal-Gel
Vitamin E enema & occasional Rowasa enema
AloeVera juice

Posted 9/18/2007 7:25 PM (GMT -7)
When I was seriously flairing and willing to try anything, I found a link concerning Vitamin E enemas. So, I figured what the @#**, and gave it a try. i was surprised that it did help and after two weeks I was feeling much better. I also started heavy duty probiotics that I continue to take. For me the hardest part was getting the enemas inside me. I'm a little overweight and felt that I needed to become a contortionist with such a small amount of fluid. You can always give it a try and be happy if it works for you. It certainly does not cost much!
  • LINDA

         

Prescriptions: Lialda (on a study) asacol, hycosamine, protonix, synthroid, zyrtec, avalide, nasocort, Miacalcin spray and Trazadone for sleep.

OTCs:  Usana multivitamins and multiminerals, Usana Procosa, Usana Mega Antioxidants, Omega 3, Vit. E,  Healthy trinity probiotics, Calcium Citrate


Posted 9/20/2007 5:19 PM (GMT -7)
thanks for the helpful info.

any other people out there who would like to share their experiences with Vitamin E enemas  - has it worked for you??

comments???

C

Posted 9/20/2007 9:53 PM (GMT -7)
Sheldon,
Do you make money selling UC related information or products?

 

Posted 9/21/2007 3:55 PM (GMT -7)

I asked that question, Sheldon, because for years I have tried to beat you into submission and confess that you really don't have a "cure" for UC. I remember when you first started telling me about this vitamin E enema plus diet thing (not sure if you originated it). At first you gave instructions via email--now you belong to the site (kind of a disease catch-all web site). It seems strange to me that someone devotes so much of their time promoting a method to "cure" UC without gaining any benefit from it. Either there's something in it for you or you need a huge pat on the back from me.

Now to the point...

Please, in laymens terms, explain (briefy) why it is you believe vitamin E (plus the diet) cures UC. I don't want the general "vitamin E is known to heal, it's a great antioxidant, it helps bla, bla, bla stuff" or the super techincal long winded version; but please, please inform me as to what happens in one's immune system when topically appied vitamin E (plus the diet) is used per your instruction then one eventually no longer has an autoimmune disease? I really want to know and tried to learn this from you posts and emails from that site you point to but to no avail.

Thanks. 

 

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