Imuran vs 6-mp

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Date Joined May 2006
Total Posts : 47
   Posted 9/21/2007 6:48 PM (GMT -6)   
Hi again.  Thought I would start a new post rather than try to combine my two questions into one.  That said, after my scope today, my GI noted that we would talk about starting an immunomodulator at my return visit this Thursday.
My question is- what is the difference between the two?  Is one easier on you than another (I've heard about nausea with Imuran), and anyone's personal experience.
I was diagnosed two years ago with left sided UC and had a scope the past two years in June.  I developed an eye condition in July (Iritis) that is associated with IBD's.  I decided to seek out a new GI and she wanted to do another scope for herself.  She is concerned that I have Crohn's and not UC- I have a skin tag, Iritis.  Anyway, the scope showed inflammation from rectum up 25 cms and a narrowing from 12-15 cms.  She took biopsies. 
Anyway, enough rambling.  Any personal experience would be appreciated!  Just wanting to educate myself.
Left sided colitis, dx'd June 2005
Colazal 9 a day
Rowasa Enamas as needed
Culturelle Probiotic
Metformin 2000mgs/ day

Forum Moderator

Date Joined Apr 2004
Total Posts : 23551
   Posted 9/22/2007 6:32 AM (GMT -6)   
Imuran breaks down into 6mp in the liver and for some their body needs that breakdown in order for it to work properly. I don't know the schmatics behind it though. My GI said that some people respond better to one or the other. He started me on 6mp due to some liver enzyme count from the Prometheus test. He said that I would probably respond better to that then Imuran. It takes a while for either one to work. I didn't start seeing a difference until I was on 6mp for 7 weeks which was super fast according to my GI. In the beginning, I had slight nausea, fatigue and headaches but when I started taking it at night, these symptoms went away because I was sleeping thru them.
Left sided Uc -'92 - Colazal, Canasa, 6mp, Prilosec, Biotin, Forvia
Secondary Reynauds Syndrome - '04 - Norvasc
Fibromyalgia - '06 
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@


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