remicade & Lupus-Like symptoms

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poohbear37
Regular Member


Date Joined Feb 2007
Total Posts : 98
   Posted 10/4/2007 3:09 PM (GMT -7)   
I have been struggling for a couple of months, most recently more sever with joint/muscle pain, fever, and extreme fatigue. Today I went for a bunch of tests. My Primary care thinks i may have developed lupus like symtoms from my remicade treatments. I have read about this happenieng. Has anyone here experienced this? and if so, how is it treated? remicade has been helping my UC so if i go off it I dont know what ill do!
~*~Kristyn~*~
Age - 24
Diagnosed w/UC at age 18
Fibromyalgia & Chronic Fatigue at age 16
Current Meds - Asacol (12 pills daily)
-Remicade (6th infusion)
-Canasa suppository (1000mg at bedtime)
-Lexapro (10mg)
-Prednisone (40mg when flaring)
-Multivitamin, Aloe Vera Gel


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7122
   Posted 10/4/2007 4:38 PM (GMT -7)   
I have had Remicade induced lupus-like symptoms. I developed the problem about 6 months after starting Remicade. I had a pretty high anti-dsDNA titer which is indicative of a possible problem. The symptoms resolved in about a week and I never had any more lupus like symtpoms. I stayed on Remicade for another 2 years after this incident. My GI and rheumy were concerned that diseases would steadily worsen without the Remicade. My rheumy monitored me closely by having a battery of blood work every 4 weeks to make certain that I didn't develop lupus outright.

Are your episodes of joint pain and fever related to when you get your infusions? If you are having these episodes within a week of getting your infusion, they should also check to see if you have developed antibodies to the Remicade.

Some people immediately stop Remicade when they develop either a positive ANA or anti-dsDNA antibodies. However I did not because the presense of these positive titers in a known consequence of anti-TNFs. In clinical trials about 35% developed the antibodies/positive ANA but had no other clinical signs. One person in the study did develop lupus. I hope your PCP sends you to a rheumatologist to have your joint issues evaluated. There are other autoimmune joint issues that can occur in people with UC and CD.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?
 


poohbear37
Regular Member


Date Joined Feb 2007
Total Posts : 98
   Posted 10/4/2007 4:53 PM (GMT -7)   
Thank you...that is very helpful. My PCP is getting my ANA checked I know that...it is one of the millions of blood tests i got today. She had mentioned seeing a rheumatologist based on the results of the blood work. Typically the symtoms happen about 2-3 weeks after an infusion (most severe) but they seem to be pretty consitant leading up to my next infusion. The symtoms are definatly not going away. Im hoping that the blod work will reveal something helpful. Thi sis getting very frustrating.
~*~Kristyn~*~
Age - 24
Diagnosed w/UC at age 18
Fibromyalgia & Chronic Fatigue at age 16
Current Meds - Asacol (12 pills daily)
-Remicade (6th infusion)
-Canasa suppository (1000mg at bedtime)
-Lexapro (10mg)
-Prednisone (40mg when flaring)
-Multivitamin, Aloe Vera Gel

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