Deficiency of Immune System Peacekeeper Pinpointed in Mice as Cause of Ulcerative Colitis

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Reef08
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Date Joined Dec 2005
Total Posts : 267
   Posted 10/5/2007 7:01 AM (GMT -7)   

MitzMN
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Date Joined Feb 2007
Total Posts : 622
   Posted 10/5/2007 8:25 AM (GMT -7)   
Wow. Very, very interesting. Thanks for posting that.

Mitz
Sporadic proctitis since about 1985. Mother had UC, then J-pouch surgery 1983.
DX'd with clostridium difficile in 2000. Prednisone, two courses of Flagyl, then Vancomycin finally got rid of it. Symptomatic with UC after that.
Colonoscopy in 2001 dx'd left-sided UC. Was pretty darn ill at that time. Treated with prednisone, Rowasa, Asacol. Asacol not working so switched to Imuran. Three small flares since in 2002, 2005, and 2007.
Gall bladder attack 6/13; ultrasound showed stones; surgery before end of 2007.
100 mg Azathioprine and 225 mg Effexor XR (for chronic, longstanding depression) daily.


schrek-chewbacca hunk
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Date Joined Jun 2005
Total Posts : 2666
   Posted 10/5/2007 8:27 AM (GMT -7)   

I agree...what a wonderful post.  Always keeps me positive and motivated to keep on movin on.

love and hope to all here

bob


hedgehog
Regular Member


Date Joined Jul 2007
Total Posts : 102
   Posted 10/5/2007 8:41 AM (GMT -7)   

Thanks for that article...really interesting!

Tara


-female - 32 -diagnosed June 2006
-last 25cm of colon affected
-Salofalk enemas stopped working
-Budesonide enemas stopped working
-xylocaine enemas - now in remission I think!! 
-Asacol 2 800mg pills 2x/day
-trying to eat less sugar and carbs


Red_34
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Date Joined Apr 2004
Total Posts : 23549
   Posted 10/5/2007 8:54 AM (GMT -7)   
I have to see my GI in a few weeks and I am printing this out for him to see in case he hasn't seen it yet. This is sort of exciting!
 @--->--SHERRY--<---@
Left sided Uc -'92 - Colazal, Canasa, 6mp, Prilosec, Biotin, Forvia
Secondary Reynauds Syndrome - '04 - Norvasc
Fibromyalgia - '06 
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
 
 
 
 

 
 


Old Mike
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Date Joined Jan 2007
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   Posted 10/5/2007 10:23 AM (GMT -7)   
You can get the complete paper here. Old Mike

dakotagirl
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Date Joined Apr 2006
Total Posts : 3402
   Posted 10/5/2007 5:13 PM (GMT -7)   
Score another one for probiotics!

Thanks for sharing! That was a very informative article :)
Pan-colitis and GERD diagnosed May 2003
 
Asacol 12 per day,  Azathioprine 75mg, Rowasa and Canasa as needed
Aciphex, Effexor XR, BCP, Rhinocort nasal spray
Culturelle, Biotin, Folic Acid, Forvia, Calcium, and B12
 
Osteopenia (hip and spine) from prednisone use.  Started Azathioprine because I was steroid dependent.
 
Co-Mod for the UC forum
Keep HealingWell running smoothly:  www.healingwell.com/donate


AlabamaBabs
Regular Member


Date Joined Jul 2007
Total Posts : 172
   Posted 10/5/2007 5:36 PM (GMT -7)   
Exciting! Wow! I was going to call my GI nurse today and talk about taking probiotics. Now I will definitely call on Monday. Thanks for sharing!
AlabamaBabs
Pancolitis diagnosed 5/07 
started on 2 Lialda/day and increased to 4 Lialda/day since 8/01/07
40 mg. Prednisone for two weeks starting 9/16/07 and tapering by 5mg per week started 9/28/07
Activia yogurt; multi-vitamin; extra calcium supplement; omega 3's


quincy
Elite Member


Date Joined May 2003
Total Posts : 29859
   Posted 10/6/2007 12:29 AM (GMT -7)   
thanks for the links Reef and Old Mike!!
Interesting.

q
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 3rd night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals 
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Horus
Regular Member


Date Joined Feb 2007
Total Posts : 190
   Posted 10/6/2007 8:10 AM (GMT -7)   
The part about it being communicable is disturbing but really nothing new here for me as I run across work almost weekly that sounds like this. The problem is that there must be dozens and dozens of ways to induce colitis. This is just one of many. And really this is meant only for those with UC that respond to anti- TNF-A therapy. Not very many people with UC respond to any sort of anti-tnfa treatment. That is why it was never initially given approval for payment by the insurance companies as a treatment for UC. It's interesting work but next week they'll have something new and different that sounds just as substantial as this. I'll post some instances of some examples of how many different ways there are to induce colitis just to give people an idea of the various ways. This is but one tiny sliver of the pie. But it's always nice to see they keep finding stuff out.

Old Mike
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Date Joined Jan 2007
Total Posts : 3790
   Posted 10/6/2007 4:57 PM (GMT -7)   
Yes find the disturbing part to also be that it is communicable, they did a study in France and the number of spousal pairs with UC that they found was greater than chance.
From this work it seems that the colon bacteria in T-BEt deleted mice somehow adapt and become pathogenic to wild mice and cause UC. Scary. Old Mike

Old Hat
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Date Joined Feb 2007
Total Posts : 5135
   Posted 10/7/2007 9:00 PM (GMT -7)   
Very interesting posts, Reef & Old Mike-- many thanks! There is a researcher at Cornell U. Veterinary School studying UC in cats & dogs-- maybe he & L. Glimscher's Harvard group will share info. & replicate mouse studies on the "higher level" mammals to further advance findings. / Old Hat (nearly 30 yrs with left-sided UC; currently on 5 Colazal daily for July flare in descending colon; should be back in remission again soon)

love4cats
Regular Member


Date Joined May 2007
Total Posts : 458
   Posted 10/9/2007 9:46 AM (GMT -7)   
It is very disturbing that this may be communicable. It also tells me that food may not cause UC, it is extremely important for us to watch what we eat to keep the good bacteria levels up, and the bad ones down.
 
 
Dx:  2006
 
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence.
 
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
 
Added: tumeric and probiotics.
 
 


Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 10/9/2007 11:30 AM (GMT -7)   
Great... We're going to be lepers...
Male 36yrs old. Indeterminate Colitis 6 yrs.


Lialda 2 a day

Protonix
multi vitamin


Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 10/9/2007 11:32 AM (GMT -7)   
They dont say how its passed...
Male 36yrs old. Indeterminate Colitis 6 yrs.


Lialda 2 a day

Protonix
multi vitamin


love4cats
Regular Member


Date Joined May 2007
Total Posts : 458
   Posted 10/9/2007 11:46 AM (GMT -7)   
Thought they mentioned through fecal cross contamination?
 
 
Dx:  2006
 
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence.
 
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
 
Added: tumeric and probiotics.
 
 


Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 10/9/2007 11:51 AM (GMT -7)   
Ahhh. I missed that.. Good reason to have your hands washed really really well.. I think.
Male 36yrs old. Indeterminate Colitis 6 yrs.


Lialda 2 a day

Protonix
multi vitamin


Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 10/9/2007 12:25 PM (GMT -7)   
A quote..

"The disease was even “horizontally” transmissible from T-bet-deficient adult mice with ulcerative colitis to other adults with normal T-bet, through fecal-oral and skin-to-skin contact."

skin to skin means by simple touch.. No?
Male 36yrs old. Indeterminate Colitis 6 yrs.


Lialda 2 a day

Protonix
multi vitamin


schrek-chewbacca hunk
Veteran Member


Date Joined Jun 2005
Total Posts : 2666
   Posted 10/9/2007 1:41 PM (GMT -7)   

Wow, I really didn't pick up on that until you all did.  It is disturbing to think that I could infect my wife with this horrible disease.  Dear God, something else to worry about now!

love to all

bob


Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 10/9/2007 1:47 PM (GMT -7)   
Somebody call a doctor that will actually pick up a phone and find out about this communicable mess !!!
Male 36yrs old. Indeterminate Colitis 6 yrs.


Lialda 2 a day

Protonix
multi vitamin


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5135
   Posted 10/9/2007 4:01 PM (GMT -7)   
Keep in mind that mice are faeces-eaters-- before you panic over likelihood of UC communicability btw humans!!!!!!!!!! / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

AKB
Veteran Member


Date Joined Mar 2006
Total Posts : 992
   Posted 10/9/2007 4:33 PM (GMT -7)   
as Horus mentioned, it probably IS communicable-- how did WE get it? If UC is genetics + an environmental trigger (likely a pathogen), then that trigger could very feasibly come from other humans (or animals, or airborne, or...).

It still requires a genetic defect, or everyone on the planet would have UC, MS, etc.
Dx:

Left-sided UC, Jun 2005. Flex-sig only... clear for first 20cms, then inflamed through next 30cms.

Therapies:

Pharmaceutical: Pentasa 3G/day, hydrocort 1x every 7 days
Probiotics: Acidophilus Pearls, Primadophilus Bifidus
Naturals: Caprylic Acid, Methylated B-12, Vit ACDE, Zinc (w/copper), Selenium, Turmeric, Bromelain, Luteolin
Killer Foods: Soda, Fried Food (especially french fries!), Beer, Red Wine, Pepperoncinis


AKB
Veteran Member


Date Joined Mar 2006
Total Posts : 992
   Posted 10/9/2007 4:37 PM (GMT -7)   
also interesting: "The researchers showed that such (TNF-a) antibody drugs cured and also prevented ulcerative colitis in T-bet-deficient mice."

Sorry, no one is being cured by Remicade (anti TNF-a), so (unless this is a gross misquote by the reporter) the limits of this mouse model reveal themselves.
Dx:

Left-sided UC, Jun 2005. Flex-sig only... clear for first 20cms, then inflamed through next 30cms.

Therapies:

Pharmaceutical: Pentasa 3G/day, hydrocort 1x every 7 days
Probiotics: Acidophilus Pearls, Primadophilus Bifidus
Naturals: Caprylic Acid, Methylated B-12, Vit ACDE, Zinc (w/copper), Selenium, Turmeric, Bromelain, Luteolin
Killer Foods: Soda, Fried Food (especially french fries!), Beer, Red Wine, Pepperoncinis


relativelyquantum
Regular Member


Date Joined Sep 2007
Total Posts : 196
   Posted 10/9/2007 6:12 PM (GMT -7)   
Remicade is also partially mouse and partially human derived, as I understood from my GI, which is why having repeat treatment does not usually work for individuals that have their immune system attack this foreign substance. Could that be why it does not work with everyone?

The communicability is a little strange. I could understand the bacteria, but not the disease itself. I guess we'll have to wait to hear more.
Pancolitis '04
Yet to go into remission, Flare-up since Aug 12th and still atempting to work in the midst of it
On Lialda (2/dy), probiotics, Oriental Medical Tea & Prescribed Diet, Greens+, Fish Oil


doors12
Veteran Member


Date Joined Jul 2006
Total Posts : 636
   Posted 10/9/2007 7:19 PM (GMT -7)   
love4cats...

Not to hijack the thread but I notice you put that garlic helps your flares. I may have noticed a similar effect on me. I may have to do a little food experiment.
Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Affecting Transverse Colon
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo, Biotin
In remission about 2-3 months after E.R. but not back to normal!
 
~Interested in finding a cure/making sense out of U.C. and philosophical and psychological aspects of UC and "Stress" and Personal Development issues with Chronic Illnesses. 

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