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Rx: (Phase 3) Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Si

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Ulcerative Colitis
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Sultan
Regular Member
Joined : Jan 2006
Posts : 250
Posted 10/10/2007 9:51 AM (GMT -8)
http://www.medicalnewstoday.com/articles/84496.php

Promising Phase 3 Trial Results Show Novel Biologic Therapy
Ustekinumab (CNTO 1275) Significantly Improved Psoriasis
Article Date: 04 Oct 2007 - 0:00 PDT

The first reported findings from an international, Phase 3 study
showed that more than two-thirds of patients with moderate to severe
plaque psoriasis receiving two doses of ustekinumab (CNTO 1275)
achieved at least a 75 percent reduction in psoriasis at week 12, the
primary endpoint of the study, as measured by the Psoriasis Area and
Severity Index (PASI 75). Importantly, findings also showed that
following one additional dose at week 16, a substantial proportion of
patients receiving ustekinumab maintained a PASI 75 response through
week 28. Data from the study, presented at the World Congress of
Dermatology, involved more than 1,200 subjects and showed that within
four weeks of initiating treatment with ustekinumab, patients
experienced significant and clinically meaningful improvements in
quality of life measures compared with patients receiving placebo.
Ustekinumab is a new, fully-human monoclonal antibody with a novel
mechanism of action that targets the cytokines interleukin-12 (IL-12)
and interleukin-23 (IL-23), and is currently in Phase 3 development by
Centocor, Inc. for the treatment of moderate to severe plaque
psoriasis.
...

Interleukin-12 and Th1 immune response in Crohn's disease:
pathogenetic relevance and therapeutic implication.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=17007011&cmd=s...

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Harpo
Regular Member
Joined : Jul 2007
Posts : 262
Posted 10/10/2007 10:35 AM (GMT -8)
But this is the Colitis forum..
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