Thanks for the quick response. I think 21 years ago when I first got this I was briefly tried on the straight sulfa and it made me very nautious. I have never tried that slow tolerance method beginning say with 1/16th of a tablet and so forth, because over the years GI's have always dismissed the old sulfa. I will ask my current GI about
trying that, since every other approach to 5ASA has been disastrous.
Interestingly, it is asacol, colazade et al that seem associated with reduced incidence of UC getting cancerous, not the straight sulfa, I believe. But irrelevant for those of us who can't remotely tolerate the stuff.
Re PD- I have tried going off it for up to a week or so without effect, but I just ordered a big batch of other probiotics without the soil-based organisms and will try those for a couple weeks. On balance the probiotics I take (including PD) seem to stabilize things a little bit.
Pancolitis dx'd 1986, full med-free remission 88-97
Flaring or simmering ever since
10 20 mg pred, 100 mg Imuran
Probiotics (mainly Primal Defense)
Turmeric/circumin, various vitamins/minerals,
Low-carb version of Specific Carb Diet