Every 5ASA med I have ever taken has worsened my UC. Just wondering how many others here have experienced this. Over the years I tried several different brans (asacol, dipentum, colozal and lialda) and the same thing happens, within 6-12 hours and even at the bare minimum dose- extreme abdominal pain, cramps, watery D, and bleeding. And every time, GI's try and suggest grinning and bearing it to see if I become tolerant. Not for me, thankyou. Not going near them anymore but it is frustrating because there is no real maintenance drug out there apart from some very heavy hitters like the biologic therapies.