Meds aren't working like they used to

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New Member

Date Joined May 2007
Total Posts : 19
   Posted 10/18/2007 7:46 PM (GMT -6)   
Hi everyone, a newbie here.  I was diagnosed earlier this year and at first, the Asacol/Rowasa combo worked great.  So great that I thought maybe I didn't have UC after all and nearly dropped the meds.  Then, the symptoms came back, so for several months, I was compliant with the meds and the symptoms were livable.  But lately, despite being compliant with the meds, the symptoms are getting worse, not better!  I get C and bloated in a flare (which made me doubt the diagnosis since everyone talks about having D!! - and losing weight - I think I've gained lbs with this), and blood, mucus, urgency, mouth ulcers, sore tailbone, even cramps if really bad.  Any ideas on what I can try to get better?  More Asacol?  Different meds?  I haven't tried modifying my diet but I haven't noticed any food triggers either.  Thanks for reading.

Diagnosed in 2007 with left-sided UC
Meds: Asacol (6/day), Rowasa

curly girl
Regular Member

Date Joined Feb 2007
Total Posts : 58
   Posted 10/18/2007 7:56 PM (GMT -6)   
When I started to get symptoms again, I talked to my doctor and he upped my asacol from 6 to 12. I guess 6 is the maintance dose and 12 is treatment/flare up dose. I've been slowly tappering them back down (1 per week). I'd chat with your doctor and get their thoughts.

Diagnosed with UC January 2007
Responding well to Asacol 2 pills 3 times per day
Asacol upped to 12 per day until the flare is under control
Canasa added nightly until the flare is under control

Elite Member

Date Joined May 2003
Total Posts : 30986
   Posted 10/18/2007 10:10 PM (GMT -6)   
Hi..I can relate to the frustration. How long have you been on the med regimen? is your UC throughout your colon or limited?

When was your last c-scope?

Are you on the Rowasa nightly?

Have you contacted your doctor considering you haven't improved a should have stool samples checked to make sure you haven't got anything else happening in the colon/digestive tract that you could have picked up and flourishing in there.

How many times a day are you going?

Hang do need to see the doctor and get reevaluated.
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Old Hat
Veteran Member

Date Joined Feb 2007
Total Posts : 5190
   Posted 10/23/2007 10:15 AM (GMT -6)   
Don't go off meds without consulting a gastroenterologist familiar with IBD. If you have mouth sores, Crohn's disease is a possibility. / Old Hat (nearly 30 yrs with left-sided UC; currently taking 3 Colazal daily; seem to be back in remission)

Elite Member

Date Joined Feb 2004
Total Posts : 20577
   Posted 10/23/2007 11:32 AM (GMT -6)   
On the same hand mouth sores are also common with UC as well so that alone is not a guide...thing about taking maintenance drugs means you have to stay on them even while in remission from my understanding, to lessen the chance of disease activity re-appearing again...if you go off them while feeling well (remission) then it increases chances of flares.

My bum is broken....there's a big crack down the middle of it!  LOL  :)

New Member

Date Joined May 2007
Total Posts : 19
   Posted 1/7/2008 11:52 PM (GMT -6)   
You guys rock. I need to check back more often, obviously...didn't even see these last few responses, sorry! I did go meet with my GI and went up to 9, then 12 Asacol, plus nightly Rowasa (it's been this routine for 10 mos. now - two of which on the elevated doses). Everything seems to be getting better except for the blood, which still makes its appearance at least once a day, sometimes even on its own. And, I have the feeling that if I went off the meds it would all go downhill again. My GI said it was live with it or change the meds - seemed to be Prednisone would be the next way to go, and I feel too well to resort to that.

I did wonder that about the canker sores - whether this might actually be Crohns - but then I saw some others here had them too. So, I guess I just wait and see on that one. Wouldn't my biopsies have shown Crohns? Apparently they were consistent with UC.

quincy - thanks for your reply on the other post.... initially my doctor thought it was maybe an impaction.  I went on one of the IBS drugs and it was awful.  It got things moving but I just felt horrendous, worse even.  After my c-scope he told me I had UC and put me on the UC meds, which initially worked so well I thought I was cured forever.  So I didn't question the diagnosis until I just kept reading that D was the symptom, not constipation.  I guess I just need to get over it already, but it's hard to justify all the pills and stuff without being 100% sure why you're taking them (besides the fact that I do seem to do better on them). 
Diagnosed 3/07 with left-sided UC
Meds: Asacol (9+/day), Rowasa

Post Edited (danile) : 1/7/2008 10:28:04 PM (GMT-7)

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