More Info UC Fungal Connection

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Old Mike
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Date Joined Jan 2007
Total Posts : 3790
   Posted 10/19/2007 8:32 AM (GMT -7)   
Here is a new abstract. Old Mike
 
Studies on the influence of Candida fungal colonization on the healing process of inflammatory lesions in the colon in rat animal model]
[Article in Polish]

Katedra Fizjologii Klinicznej i Doświadczalnej, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.

Present-day methods of successful treatment of inflammatory bowel diseases (IBD) result from a better understanding of their pathophysiology due to advances in preclinical studies in this area of knowledge. Until recently microbiological studies have been focused on the bacterial aspects in pathogenesis of GI disorders, however in the last years an interest in the presence of fungi in the gastrointestinal tract has also increased. In this study using an animal model of ulcerative colitis, the impact of fungal colonization of the colon on the intensity of inflammatory changes in the colonic mucosa and the course of their healing was carried out. The macroscopic and microscopic criteria relating to the changes of weight of examined fragments of the colon were evaluated while assessing differences between groups tested. The intensity of intestinal inflammatory changes was determined by assessment of such parameters, as colonic blood flow (CBF), the level of MPO as a marker of colonic neutrophil infiltration intensity and the plasma levels of IL-1beta; and TNF-alpha concentrations. Results at the 3rd day after TNBS rectal administration revealed an increase of weight of isolated segments of inflammed colon, a decrease of CBF and the 4-5 fold increase of plasma MPO activity. Candida colonization of colon mucosa of rats delayed healing of colonic ulcers, induced by TNBS and this was associated with the increased expression of plasma IL-1beta and TNF-alpha levels. Administration of antifungal (fluconazole) or probiotic (Lacidofil) treatment to C. albicans infected rats exerted favorable effect on healing of inflammatory changes in the colon because the area of ulcerations in groups of rats treated with fluconazole or Lacidofil was significantly smaller in comparison with those inoculated with Candida solution only. Administration of fluconazole or Lacidofil significantly decreased the weight of colon segments, the MPO activity and the plasma IL-1beta and TNF-alpha levels, as compared with respective values in the group receiving Candida only. The results of our studies indicate the deteriorating influence of Candida on the healing process of inflamed colon in the animal model of ulcerative colitis. Concomitant therapy with probiotic or antifungal treatment improved healing of colonic lesions, decreased the weight of inflamed colonic tissue and also attenuated the MPO activity and plasma proinflammatory cytokines IL-1beta and TNF-alpha levels


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2198
   Posted 10/19/2007 10:02 AM (GMT -7)   
Old Mike said...

The results of our studies indicate the deteriorating influence of Candida on the healing process of inflamed colon in the animal model of ulcerative colitis. Concomitant therapy with probiotic or antifungal treatment improved healing of colonic lesions, decreased the weight of inflamed colonic tissue and also attenuated the MPO activity and plasma proinflammatory cytokines IL-1beta and TNF-alpha levels

Interesting. When I first came to this forum, I was attacked when I said my problems had a candida-related component.
Diagnosed with ulcerative colitis spring 1999
C-scope confirmed UC diagnosis 9/18/2007
No explanation for right side pain and thickening of bowel wall
 
Maintenance dose sulfasalazine, back on a pred taper for first flare in years
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal.
 
 


DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 10/19/2007 10:25 AM (GMT -7)   
thanks Old Mike. I have just started the antifungal diet again, this time I am sticking to my guns. 4 Days now of the initial diet, 10 more days to go. Its from the book the Fungus Link. I have done it before, but never 100%. I took diflucan for 2 weeks and about 3 days after taking it my bm's got cut in half, but I didnt diet at all, so it didnt get any better. My caprylic acid should be in today, and I see my GI on Nov 7th, I am going to see if I can get on diflucan for 2 more weeks.

I am also on Humira and it seems one of the side effects is invasive fungal infections. I am hoping that the LDN I take at night will counter that, but at this point I dont want to take that chance. I am probably going to stop taking it.

Princesa some people feel that since that have had this disease for decades they are entitled to differentiate between what causes UC and what doesn't. However, if this were the case they wouldn't have UC anymore. So I don't and you shouldn't pay any attention to them.
4.5 mg of LDN.
Humira
NSI Candida Yeast Management


love4cats
Regular Member


Date Joined May 2007
Total Posts : 458
   Posted 10/19/2007 5:20 PM (GMT -7)   
That's interesting. I stand by my claim that fresh crushed garlic does make my stomach better during flares. I have had three flares and in all three I managed to stay away from prescription drugs by eating garlic daily. It is a natural fungicide/antibiotic

The other thing is that candida production increases with increased progesterone levels (flares worse during women's periods), increased refined sugar intake, and antiobitic overuse? Could there be a connection or is it just coincidence?
 
 
Dx:  2006
 
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence.
 
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
 
Added: tumeric and probiotics.
 
 


relativelyquantum
Regular Member


Date Joined Sep 2007
Total Posts : 196
   Posted 10/19/2007 5:53 PM (GMT -7)   
What a great read! I've been wondering if there was at least some connection when a lady told me about controlling one's pH levels and in doing so it also minimizes yeast growth... there is a book called the "pH miracle" that was mentioned. Has anyone read this? I glanced and didn't see any mention of IBD. Though I was intrigued by this idea, she really didn't have any proof. As I've read that yeast overgrowth can occur with antibiotic treatment and diet, the idea seemed more plausible. I think I'll try some natural (food) supplements to see if it will help me.

Let us know how your treatment goes Danthaman.
Pancolitis '04
Yet to go into remission, Flare-up since Aug 12th and still atempting to work in the midst of it
On Lialda (2/dy), probiotics, Oriental Medical Tea & Prescribed Diet, Greens+, Fish Oil


kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 10/19/2007 6:05 PM (GMT -7)   
Thanks Old Mike. Danthaman...good luck! You can do it :) I also share that belief, that fungus is the cause of a lot of our health issues. I am healed from UC from following an antifungal program, as well....actually, the same that you refer to. So, keep the faith. Give it time. You didn't get sick overnight. Those who may wish to check out more info on fungus may peruse the website, knowthecause.com. Some good articles/links there. Also lists the diet/program under FAQ's. Or, you can email me and I'll send it to you. The first step to getting better is 'change'. Take care all.........

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 10/19/2007 7:21 PM (GMT -7)   
Good article, Mike. I have always wondered about fungus and candida concurrent with my UC, but I keep testing negative when I get a stool analysis. Having bene on prednisone on and off for years, I'd expect it, and maybe it is a player in the intractability of my case, but it hasn't been showing up.
Pancolitis dx'd 1986, full med-free remission 88-97
Flaring or simmering ever since
10 20 mg pred, 100 mg Imuran
Probiotics (mainly Primal Defense)
Turmeric/circumin, various vitamins/minerals,
Low-carb version of Specific Carb Diet
 
 
 


kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 10/19/2007 7:37 PM (GMT -7)   
Never showed up with me either. The only way I knew it was fungal for me was to experiment (even when my doctor said there was no such problem and not to bother!) by following an antifungal diet and taking natural antifungal supplements. I was as big a skeptic as anyone. (Wouldn't my doctor have known about this, after all?!) Within days, I knew I was onto something. 2 weeks later, all my symptoms were pretty well gone. I also had more energy and "joie de vive" than I had in a very long time, as well. Extra bonus :) I remain on a somewhat modified antifungal diet even now, along with the natural antifungals and probiotics, for maintenence. I don't want anymore problems!

relativelyquantum
Regular Member


Date Joined Sep 2007
Total Posts : 196
   Posted 10/22/2007 7:53 PM (GMT -7)   
It should also be noted that everyone has candida in their system, but usually it is quite small and/or well behaved/kept in check by our flora. I don't know how those tests are performed, but I assume they are looking for an abundance of the fungus or maybe it is just not as definitive as we are lead to believe.
Pancolitis '04
Yet to go into remission, Flare-up since Aug 12th and still atempting to work in the midst of it
On Lialda (2/dy), probiotics, Oriental Medical Tea & Prescribed Diet, Greens+, Fish Oil


tru-believer
Regular Member


Date Joined Dec 2006
Total Posts : 329
   Posted 10/22/2007 8:27 PM (GMT -7)   
 
   Ever read the fungal etiology of inflammatory
   bowel disease?  its a good read
 
 
   Fact is refined sugar is highly inflammatory,
   and yeast intake can lead to bloat, and
   obesity, high blood pressure, high
   cholesterol.  Diet high in sugars, grain gluten
   or alcohol can set up the very conditions
   that make you crave more and more of
   this stuff as you accumulate more fungus
   and yeast in your tissues.  Later fungal
   sacks can develope that are carbon
   copies of cancer tumors, and fungus
   can even combine with and knock out
   your normal DNA>  This is the stage
   that will kill you.  Candida as mentioned
   above will overgrow the intestinal tract
   and keep you from forming stools and
   eliminating at all.   You can get rid of
   this in 30-45 days through use of
   anti-fungals, nystatin, nyserol, or
   otc herbs such as caprylic acid,  olive
   leaf extract, or oral intake of oil oregano.
   This is no joke.
   Causative factors for fungal overgrowth
   beside diet it mold ingestiion through
   infested living quarters,  or heavy 
   use of antibiotics,  dropping your immunity
   to you are more suceptable to mold/fungus.
  
   This is not believe it or not or tabloid.  This regimen
   does work to achieve permanent remission
   for many people.  Im another one that did it.
 

tru-believer
Regular Member


Date Joined Dec 2006
Total Posts : 329
   Posted 10/22/2007 8:32 PM (GMT -7)   
 
     The proper article is the 4th item down on
     the list on google.
      tb

Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4034
   Posted 10/22/2007 9:03 PM (GMT -7)   
How can you get tested for fungus in your system? Someone above mentioned stool samples...I know I had one a while back for parasites, e coli and c. diff. Are there other tests that can be done?
23 years old
Diagnosed with UC March 2007
Current inflamation in the rectum
Asacol 4 tablets 3x/day
Rowasa (generic) - nightly
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; experimenting w/fiber supplements (Metamucil and Fiber Choice); Viactiv (Calcium and Vit. D) for Osteopenia; ground flaxseed


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 10/22/2007 9:50 PM (GMT -7)   
I fully agree with you true-believer, unfortunately some don't, that's usually why there are so many disagreements about diet and IBD.


:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 10/23/2007 4:25 PM (GMT -7)   

Thanks Tru- for the reminder again. I'm glad to see you are still lurking about. :)

Kim


UC Fighter
Regular Member


Date Joined Oct 2007
Total Posts : 89
   Posted 10/27/2007 4:16 PM (GMT -7)   
This is really fascinating. They're always saying they don't know what "causes" the inflammation. THe root of the problem right?
If it were a fungus then things like sugar, carbs and starches would be horrible things to eat (as they would feed a fungus). Does anyone here avoid those types of foods? To be honest, I've been flaring for 2 months and eating mostly carbs and sugars because they were "easy" to digest, HOWEVER I haven't made hardly any progress.

At this point, I'm ready to shift gears and avoid the sugars, carbs etc to see if that helps.
Current Prescriptions:
 
50 mg Prednisone per day, 1 x per day
1000 mg Sulfasalazine, 4x per day
1 Mesalamine Enema per day


relativelyquantum
Regular Member


Date Joined Sep 2007
Total Posts : 196
   Posted 10/27/2007 5:41 PM (GMT -7)   
I believe that is why the "specific carbohydrate diet" works for so many people (check it out online and/or search on this site for what others have said). I totally hear you on the sugars and carbs issue, because I use to over do it and I still struggle. Not surprisingly sugars and most carbs (likely refined/processed type especially) feed the pathogenic microbes (bad bacteria and yeast) and the healthy stuff we know we should eat feed the good microbes.
Pancolitis '04
Yet to go into remission, Flare-up since Aug 12th and still atempting to work in the midst of it
On Lialda (2/dy), probiotics, Oriental Medical Tea & Prescribed Diet, Greens+, Fish Oil


DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 11/1/2007 1:38 PM (GMT -7)   
anyone know where to get enteric coated caprylic acid?

I would like to have nothing else in it, just 100% cap.

Thanks

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 11/1/2007 7:38 PM (GMT -7)   
Jumping back into this thread-- it does make me curious to try periodically (eg once a day, and timed off a few hours from any probiotics) to really 'wallop' my gut with some antifungals. But I too wish we could find more enteric coated versions, to at least get past the stomach and have a figthing chance of making it as far as the colon. (On a nother topic-- my unfulfilled dream is that someone somewhere would sell empty enteric capsules that you can self-assemble i..e fill and 'pop'/snap closed tight ... then we could try the enetric-PC i..e enteric liquid lecithin treatment that seemed to have an 80 or 90% remission rate in the clinical trial with 20 people or whatever... but those sort of capsules just don't exist on the open market.)
Pancolitis dx'd 1986, full med-free remission 88-97
Flaring or simmering ever since
10 20 mg pred, 100 mg Imuran
Probiotics (mainly Primal Defense)
Turmeric/circumin, various vitamins/minerals,
Low-carb version of Specific Carb Diet
 
 
 


kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 11/1/2007 7:59 PM (GMT -7)   
What about getting a prescription for nystatin, which fights fungus in the gut.

Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 11/1/2007 9:38 PM (GMT -7)   
Hi Kim123 and Love4Cats. I just have a couple of questions.

I really wanted to know what dose of garlic Love4Cats was talking about. Should you increase the dose slowly? Fresh garlic from the store or fresh from the garden?

And Kim123 - what natural antifungals were you talking about and at what doses? I have heard of Olive Leaf Extract...

Any pointers would be great!

Post Edited (Severin) : 11/6/2007 10:42:23 PM (GMT-7)


DeniseW
Regular Member


Date Joined Nov 2005
Total Posts : 346
   Posted 11/1/2007 10:18 PM (GMT -7)   
I agree that's probably why the scd diet works for some. Could be why it worked for me for so long. However, I think there are a ton of reasons you can have a flare, and now I just have a different reason. :(

Watch the garlic. I did that to get rid of candida (or the white stuff on my tongue) and it worked FAST. Then I tried it again to try and kill what was in my gut and was ok for a few days, but then took too much. Now I can't smell it or use the smallest amount in our foods without wanting to ralph! It's really harsh on your tummy!

It is so sad that when you're sick all you can stomach is stuff that is bad for you. :(
dx 4/05 with pancolitis UC after birth of my second child... meds worked randomly
SCD and vit e enema remission for 18 months and had another drug free baby 10/06
Let flare get out of control and even steroids wouldn't work 7/07 - docs wanted surgery
lialda x4 daily and started remicade 10/26/07
 
 


kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 11/2/2007 2:11 PM (GMT -7)   

Severin,

I use olive leaf extract and rotate it monthly with caprylic acid. Important to rotate them, or the fungus will get smart! I know oil of oregano is supposed to be good as well. I never did try that one though. It is important to eliminate the fungus feeding foods as well if you suspect your condition is fungal, or if you just want to experiment to see if it is. I did not know that my condition was fungal. It was only after I experimented with an antifungal program and felt so much better within a few weeks, that I figured it out. And, my doctor told me not to bother. Glad I didnt take his advise that time! :)

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