Yeah the Imuran will cause the headaches, no doubt. And many of the other side effects you listed (sweats, insomnia, over-eating) are likely from the Prednisone. In my case the Pred. also causes achy joints, especially my hips, shoulders. Mood swings as well, especially after being on it over a month. Glad to hear you're doing better though. When I started flaring last year, I also lost about
25 lbs (I was thin to begin with), and got down to 107 lbs (5'8 31 year old male). I'm now 140 consistantly, though I'm sure some of it has to do with the Pred. and not working a physical job anymore. That's one good effect of the Pred...the weight gain...when we need it most.