I'm assuming that you think the key to remission is because of the posts I had up earlier in the year about
mucus manipulation. In going over your remarks I noticed that you think that changing the viscosity and amount of mucus is not a viable option if it doesn't "stick" to the colon wall. I'm wondering how you come to that conclusion because you seem to be confused about
the mucus theory.
I'll begin with your statement that you think you are passing "thick mucus." You couldn't be more wrong. What you are passing is EXCESS defectively made mucus that forms in response to inflammatory signals in the colon because of the disease process and inflammation. This mucus comes out that way because it is being produces in EXCESS and thus made VISCOUS, meaning that it may be PLENTIFUL but it is thinned out and extra runny compared to how it normally is. If you bothered to read the posted medical journal references about
it that I posted before you'd know that in UC mucus is either thin or absent in the inflammed parts and was shown very clearly in PHOTOS. When mucus is THINNED out( meaning RUNNY) and becomes viscous the bacteria will cross through enmass and further aggravate and sustain the inflammation. The mucus becomes "pooled" in the rectum because it becomes so runny and that is why you think erroneously that you have THICK mucus. In reality you have just more thinned out mucus that is defective that has gathered in the rectum.
Your assumption that you have to FIRST reduce inflammation then the mucus will bond is also wrong. During the inflammation goblet cells are destroyed that make mucus and it's the goblet cells that have to come back before the mucus will be made correctly and as studies have shown, the better made less viscous mucus made by the correct amount of goblet cells, the less inflammation you will have. They have also shown that certain populations of people with UC have anti-goblet cell antibodies. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9207267&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
However, there are many many types of colitis but many of them will show this defective mucus no matter how it's caused. We have an ability as people with UC to manually manipulate this via phosphatidylcholine enemas to help THICKEN the VISCOSITY of the mucus, not increase the AMOUNT of thin runny mucus. Will this help everyone? No because of the vast variety of types of colitis. But inflammation in itself will destroy goblet cells and the mucus barrier regardless of the type of UC you have. We can change this ourselves WITHOUT having to take horrendous prescript
ion meds. Yippee. This has been gone over before.
I think we also went over the idea of proper breathing to induce the parasypathetic pathway but I found that the actual receptor it works on is the nicotinic receptor eventually and as we all know taking nicotine has not worked out to induce long term remission for the vast majority that have tried that and this breathing technique would be analogous to that.
I'm not sure your idea about
using hot peppers to induce mucus production is wise because this merely over excites the receptor that responds to the stimuli and temporarily at best stops the pain signals. Capsaicin cream is well know to arthritis sufferers and it's no long term treatment because eventually the body figures out a way to overcome the lack of this pain signal and now you have a new pain pathway upregulated that is worse than the original. Look up capsazipine and nerve ablation of this receptor and you'll see what I'm talking about
. I avoid any kind of hot peppers for this reason. It is only a short term stop gap and long term it makes things worse.
I'm glad you think that mucus manipulation is a good way to control symptoms but it looks like you think this way for the wrong reasons. Look in the archives here for old postings I have about
it. I do phosphatidylcholine enemas and have been able to lower my dose of asacol and my symptoms are basically non existant. I have tried to eliminate the asacol all together but the inflammation comes back as I'm not able to fully cover the entire colon with the enemas yet. Whatever underlying process is driving the inflammation is still there even though I use the enemas. It could be driven by an unknown virus, high phospholipase producing bacteria, antibodies, etc....However, one can substantially lessen the symptoms by getting a good mucus layer down.
Post Edited (Horus) : 10/29/2007 6:37:13 AM (GMT-6)