Hi MagiMae, and welcome to HealingWell! I've been on Remi for over two years now, and I was really lucky in that the Remi worked almost overnight for me. With other folks it has taken a bit longer, sometimes weeks, or even several infusions to feel better. Everyone is so different that it's hard to say what will work and how long it might take to work for you. I will say that it's been heaven sent for me, and I'm happy I made the decision to go the Remi route. Good luck to you with your infusion; should you have any questions, don't hesitate to ask!