6-mp and status

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New Member

Date Joined Jun 2007
Total Posts : 10
   Posted 11/6/2007 10:02 AM (GMT -6)   
I was put on 6-mp about a month ago and have been told that it can take up to 6 months for my colitis to start to heal. I am currently on 5 mg of pred and going off of it next week. I am on 4g of Pentasa a day. So starting next week I will be on 75mg 6-mp and 4g of Pentasa a day. I take a multi-vitamin daily.

My doctor went to a conference at Johns Hopkins where they said that some people do not need to be on steroids for 6-mp to work effectively. Is this true? If so, has anyone else heard it? I think the treatment is working because I seem to be going less frequently and there is less blood in the stool.

I've been flaring since early April and been on prednisone since then and that's why I'm tapering off.

Basically, is anyone else on 6-mp and can they offer advice on what they did that has helped them.


Post Edited (Steve11) : 11/6/2007 8:09:16 AM (GMT-7)

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 11/6/2007 10:09 AM (GMT -6)   
I think that most people that are on 6mp are steroid dependant which can be why you see many on steroids while starting this. But no, one doesn't have to be on steroids in order for it to work. I wasn't on oral steroids when I started but steroid enemas and 6mp allowed me to finally get off them. I was on them for off and on for a year. I've now been on 6mp for 1 year and it has helped me tremendously.
Left sided Uc -'92 - Colazal, Canasa, 6mp, Prilosec, Biotin, Forvia, Pro-Bio 
Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)
Secondary Reynauds Syndrome - '04 - Norvasc
Fibromyalgia - '06 
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@


Regular Member

Date Joined Oct 2007
Total Posts : 486
   Posted 11/6/2007 10:36 AM (GMT -6)   
I agree with Red. I took Prednisone in the beginning but got off it quickly. (And actually, the taper didn't work. I was still sick but I decided to tough it out and get off the Pred since I'd been on it in years past and didnt' want to take it for too long.) I continued to take DiPentum (a 5-ASA drug) in the beginning. Maybe it was a few months. I was so sick at the time that I doubt it made a difference!

I started to really get better about 8 months after starting the 6mp. I'm still on it, and this is nearly two years later. I'm not immune to flares while I've been on the 6MP but I've never flared as badly as I did before without it. So I think it's raised my baseline, if that makes any sense.

I don't take any other pills with it, which is a dream. I was really tired of taking a billion 5-ASA drugs all day. (I still use canasa and cortifoam when I start to flare.)

One note about 6mp: You really have to keep getting your blood checked often. I'm sure your doctor has told you this. :) My red blood cell count was REALLY low for months but after a year it's now completely normal! Here's what I did that I think helped:
1) took 800-1200 mg Folic acid every day
2) Split my dose of 6mp so that I took half a pill in the morning and half in the evening so that my body could better metabolize it.

I think that 6mp is probably the reason I've been having a good year UC-wise. I know they say it takes a while to kick in and I'm one rare example of it taking longer than 6 months! But it was worth the wait. I nearly gave up after month 6 and I'm glad I didn't.
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.

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