I think that most people that are on 6mp are steroid dependant which can be why you see many on steroids while starting this. But no, one doesn't have to be on steroids in order for it to work. I wasn't on oral steroids when I started but steroid enemas and 6mp allowed me to finally get off them. I was on them for off and on for a year. I've now been on 6mp for 1 year and it has helped me tremendously.
Left sided Uc -'92 - Colazal, Canasa, 6mp, Prilosec, Biotin, Forvia, Pro-Bio
Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)
Secondary Reynauds Syndrome - '04 - Norvasc
Fibromyalgia - '06
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