How do you take your Imuran?

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Regular Member

Date Joined Jul 2007
Total Posts : 77
   Posted 11/12/2007 2:16 AM (GMT -6)   
I just started taking 100mg of Imuran last week. Getting off the Prednisone was just not working and this was the next step. My GI actually gave the choice of Imuran or Remicade, but suggested Imuran because it's easier to take and the logical next step in her opinion.

Anyways, I am taking it at night because I was worried about drowsiness/nausea. The first day I felt sick to my stomach, the next couple days I was better, but still drowsy. I am having some gas in the evening, I also stopped my Asacol as per my GI's rec. My joints are a little hurty.

How do you guys recommend I take this? Should I break up the dose over the day? What about gas and such? I haven't had that for a while. I am still on 20 mg Pred, tapering to 10 mg next week and hopefully off when this Imuran kicks in! I could use some advice. I get my bloodwork done Friday.


Veteran Member

Date Joined Mar 2005
Total Posts : 2844
   Posted 11/12/2007 2:44 AM (GMT -6)   
Hey superdeejayanna,

I take 100 mg in the morning and 50 mg in the evening, when I started taking it I would vomit pretty bad for a few months but it wore off, and I got my life back.

Hope it works for you.

Take care.

Dansky Co-moderator UC forum
Citalopram Hydrobromide



Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 11/12/2007 2:24 PM (GMT -6)   
My GI says there's no medical reason to divide the dose, that you can take it all at once. So I'd say just take it whichever way works best for you.
Left-sided UC diagnosed 2001.  Taking Colazal and Imuran, Remicade infusions and moving into remission. Finally off steroids after four years! 
Now in remission for almost two years. Remicade has been my wonder drug.
"If you spend your time second-guessing your past decisions, you'll never have time to enjoy today."

Veteran Member

Date Joined Dec 2005
Total Posts : 3238
   Posted 11/12/2007 2:46 PM (GMT -6)   
I take it after dinner. Did you stop the asacol cold turkey or taper?
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-6 a day, Acidopholis Pearls, Prilosec OTC
Co-Moderator UC Forum

Regular Member

Date Joined May 2006
Total Posts : 260
   Posted 11/12/2007 3:01 PM (GMT -6)   
I take mine all at once, right after dinner.  The drowsy effects of it help me get to sleep at night, though it sometimes carries on to the next day.  That's about the only side effect I've had with Imuran so far.
---Nathan---  31 yr old male
Diagnosed May 2006 w/severe UC (pancolitis)
Currently in mild flare
2 400mg Asacol 4X day
10mg Prednisone
1 multivitamin/day
2 grams calcium/day
75mg Imuran/day
100mg Tramadol/day for abdominal pain (as needed)
1 Fioricet ever 4 hrs as needed for severe migraines

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 11/12/2007 3:27 PM (GMT -6)   
same as Nathan, I take it all at night and I think it does help me sleep. Other than that no side far (knock on wood!)

one thing the hair on my legs has pretty much stopped long as that does not happen to my head but I need to get my color touched up so I can tell it's still growing there.
Beth, 32
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 150mg 1xday nightly;Hydrocortisone enemas 1xday;Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Potassium 600mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 80mg 2xday. Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

Regular Member

Date Joined May 2007
Total Posts : 169
   Posted 11/12/2007 4:31 PM (GMT -6)   
I was taking it in the morning but seemed to be suffering profound drowsiness late morning. I tried taking it in the evening for a week or so, but then kind of started flaring. This was probably only due to prednisone tapering, but I went back to the morning (don't mess with something that is working!) I can handle the drowsiness. I take all 125 mg at once.
Dx Left-sided UC Dec. 2006
Azathioprine (Imuran) 125mg/day
Prednisone 2.5mg/day (trying to taper-started at 60 6/1)
Lialda 4/day
Multivitamin, B complex vit., fish oil, calcium, fiber supplement, probiotic

Veteran Member

Date Joined Jan 2007
Total Posts : 1015
   Posted 11/12/2007 5:22 PM (GMT -6)   
I started taking mine in the morning but like others, I would be ready to pass out in the middle of the day so i switched to taking mine at night and have had no problems. I do get headaches occasionally though...other than that I haven't noticed anyting..still waiting to see an improvement.
Kelly, 29

Left sided UC diagnosed 1/98 age 19, Pan colitis diagnosed 1/07
Currently on 4x3 Asacol, Rowasa every other night, 15 mg pred. until immuran kicks in...
75mg Imuran starting 8/23/07---bumped to 100mg 10/8/07
Prontonix once daily for acid reflux, zofran twice daily for nausea

Regular Member

Date Joined Jul 2007
Total Posts : 77
   Posted 11/12/2007 5:45 PM (GMT -6)   
I did quit my Asacol cold turkey, my GI said there was no reason to continue it if I was starting the Imuran- does that seem normal?
I plan to taper my Pred down to 10mg in a week- wish me luck. This is where I always get messed up, going from 20 to 10.

I am sleeping pretty well, at least I don't have to take my sleeping pill, Imuran is taking care of that, so I think I will keep taking it at night for now.

Regular Member

Date Joined Nov 2005
Total Posts : 346
   Posted 11/12/2007 11:39 PM (GMT -6)   
I just started last night, and I'm only on one pill (50mg), so I probably don't apply to the orginal message. My doc did keep me on the Lialda though until I get better. The imuran takes so long to start working that it seems like you shouldn't stop stuff till it's been a few months. I plan on stopping mine ASAP, but I stopped it cold turkey a while back and got sicker. I had done some other stuff too, most likely that since I didn't get better when I started the lialda, but... My doc said you don't have to taper it, but I'm just worried about stopping it before the imuran kicks in.

Good luck with the pred taper.
dx 4/05 with pancolitis UC after birth of my second child...
18 months of vit e enema and scd remission
Flare since 7/07...almost to surgery, now almost well through mostly natural stuff
Trying to make up the difference with...
Lialda 4/day
Remicade 10/26, 11/09, next 12/3
Imuran 50mg at night 11/11
Been there, tried that....

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