How do you take your Imuran?

I just started taking 100mg of Imuran last week. Getting off the Prednisone was just not working and this was the next step. My GI actually gave the choice of Imuran or Remicade, but suggested Imuran because it's easier to take and the logical next step in her opinion.

Anyways, I am taking it at night because I was worried about drowsiness/nausea. The first day I felt sick to my stomach, the next couple days I was better, but still drowsy. I am having some gas in the evening, I also stopped my Asacol as per my GI's rec. My joints are a little hurty.

How do you guys recommend I take this? Should I break up the dose over the day? What about gas and such? I haven't had that for a while. I am still on 20 mg Pred, tapering to 10 mg next week and hopefully off when this Imuran kicks in! I could use some advice. I get my bloodwork done Friday.

thanks!!!

My GI says there's no medical reason to divide the dose, that you can take it all at once. So I'd say just take it whichever way works best for you.

I take mine all at once, right after dinner.  The drowsy effects of it help me get to sleep at night, though it sometimes carries on to the next day.  That's about the only side effect I've had with Imuran so far.

I was taking it in the morning but seemed to be suffering profound drowsiness late morning. I tried taking it in the evening for a week or so, but then kind of started flaring. This was probably only due to prednisone tapering, but I went back to the morning (don't mess with something that is working!) I can handle the drowsiness. I take all 125 mg at once.

I did quit my Asacol cold turkey, my GI said there was no reason to continue it if I was starting the Imuran- does that seem normal?
I plan to taper my Pred down to 10mg in a week- wish me luck. This is where I always get messed up, going from 20 to 10.

I am sleeping pretty well, at least I don't have to take my sleeping pill, Imuran is taking care of that, so I think I will keep taking it at night for now.