Steriod Enema follow up - How long until side effects take over?

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New Member

Date Joined Jul 2007
Total Posts : 18
   Posted 11/15/2007 9:20 PM (GMT -6)   
Hey everyone,
I just met with my GI today after my lastest colonosocpy and he wants me to conitnue taking the hydrocotizone steriod enema's. I have only been on the them for 9 days (2 times a day), and he wants me to continue this for another 2 weeks, followed by 4 weeks of once a day dosage. My question is, is this too long of a dosage? This is the first time I have been on the seriod enema's, so I am wondering when the side effects will kick in? Do the enemas cause moonface and weight gain like pred? Any info would eb helpful. I can't seem to find any information online, regarding the enemas, as to exactly how long it takes for side effects to kick in. I am praying that I don't end up steroid dependent.....thanks in advance
--23 yrs old -- Left Sided Uclerative Colitis
--Diagnosed over 3 years ago
--12 Asacol daily - 3 pills/4 times - 1 Canasa
--1 Ganeden (probiotic) nightly - probiotic cereal/yogurt
--2 Centurm daily (these have helped greatly with fatigue and colds) ------2 Citrical Calcium daily
--5 to 10 Grams Gultimine daily
--One omega 3-6-9 fish Daily

Regular Member

Date Joined Apr 2006
Total Posts : 229
   Posted 11/15/2007 10:10 PM (GMT -6)   
I haven't used them for many years and the most I ever used was once a day (at night).  My GI told me that relatively little of the steroid is absorbed into the body.  I believe this is true but some definitely is absorbed. A typical course of treatment is 2 to 4 weeks.  I was once on them for 4 months.  I experienced none of the side affects you mentioned or any others associated with steroid use however when I went off of them I did experience some joint pain for a few days. They worked well for me.  I found it helpful to warm them to body temp. just prior to use

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 11/16/2007 7:05 AM (GMT -6)   
Yes, very little is actually absorbed into the bloodstream but if taken for long term, you can start to see side effects. By long term I mean longer then 6 months or so. I was on them for almost a year and it was around the 7 month mark when I started seeing the moonface. I didn't know I had it until I had some pictures taken. Your dosages sounds about right, just remember to not stop them all of a sudden when you are done with your course of treatment. You need to taper them or you can have rebound flares.
Left sided Uc -'92 - Colazal, 6mp, Prilosec, Biotin, Forvia, Pro-Bio 
Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)
Secondary Reynauds Syndrome - '04 - Norvasc
Fibromyalgia - '06 
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@


Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 11/16/2007 9:24 AM (GMT -6)   
I've been on them for 2 mos and on pred for 2.5 mos, I have moonface but that is probably b/c I am on 60mg/40mg of pred alt days. I believe the steroid e's really helped me thought it took a couple of weeks. My weight went up and down a few pounds, but today I am a couple pounds less than when I started. I have really been watching what I eat and have been trying to stay at 1500mg of salt or less a day.
Beth, 32
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 150mg 1xday nightly;Hydrocortisone e's tapering, Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 80mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

Old Hat
Veteran Member

Date Joined Feb 2007
Total Posts : 5190
   Posted 11/16/2007 10:11 AM (GMT -6)   
My early UC treatment was exclusively Cortenemas because Rowasa was not yet available. I stayed on them for as long as 3 months then tapered off. They did not have the bad side effects of Pred, such as moon face, for me. At 1st they did make me feel strong enough to break boards, a false "high", which one needs to be aware of-- so as to continue getting plenty of rest to help heal the inflamed tissue. They also increased my appetite, but it didn't harm me to gain weight at that point in my life because I was around 108 lbs & looked kinda scrawny. With extensive use they cause one's scalp hair to thin, and they can bring on yeast infections. In my case their benefits outweighed the few side effects; I had such a severe flare on diagnosis that gastro said my left-side colon "looked like raw hamburger" at c-scope & I was in danger of hemorrhage. So I would advise that you can take hydrocortisone enemas with confidence for at least a few months if you need fast relief from major UC symptoms. Be sure to eat as balanced a diet as possible & take the necessary vit/mineral supplements, such as calcium, vit D, & folic acid. Best wishes for you to feel better soon! / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily; seem to be back in remission)

Scrap Girl
Veteran Member

Date Joined Jan 2007
Total Posts : 653
   Posted 11/16/2007 10:53 AM (GMT -6)   
I did get the moon face, probably about a month after I starting using the steriod enemas. It didn't seem quite as "moony" as when I was on prednisone. 
Diagnosed with UC in Feb. 2005
Colazal (9 a day)
Folic Acid
Remicade remission

Regular Member

Date Joined Jul 2007
Total Posts : 22
   Posted 11/16/2007 11:18 AM (GMT -6)   
Sam has been on them for 2 rounds the first time it was for 10 days and it worked great, she is back on it now but it is not working well, she did not get moon face the first time but does this time but I am confidant it is the predisone
Jennifer Mom to Sam I am (14 yr old girl)
Cortifoam twice a day
35 mg Prednisone
Asacol 4 times a day @400 mg ea
6MP 1/2 tab every other day
Multi Vitamin

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