I get moon-face at 40mg, and it seems to happen overnight after taking it for a week or two. As soon as I get the moon-face, my colitis symptoms seem to start improving.
Also, instead of insomnia, I get fatigued. I know that I am in the minority on this one, but I have no issues with falling asleep while on Pred, and while I wake up feeling completely refreshed, righit around noon, I crash hard. I used to go out to my car on my lunch hour and take a power-nap, which helped.
The worst symptom for me is headaches. Terrible headaches, which again is odd because cotizone is sometimes prescribed for people with headaches! But I had issues last summer while on 20mg-40mg of pred until I stepped down to about 15.
Male - Age 39
Diagnosed in 1988
Moderate Pan Colitis 10 years ago, but mild and fairly controlled since then
40mg Pred 30mg Pred 25mg Pred 20mg Pred
Fish Oil Supp (or Flax Seed)