The only drug I tolerated after my first years of UC attack (Imuran etc weren't used yet for IBD then) was pred, and I was constantly one step forward-one back, 2 forward- 1 back, etc with that and it took me 2-1/2 years to taper off them then. Anyhow, I got into a 9 year remission on no meds at all. However, that said, I am envious of all those who seem to do well on the relatively safe 5ASA drugs, which I am allergic to. I wouldn't go cold turkey on pred, but I don't believe there are any restrictions against going cold turkey on immunosupps. or 5ASAs if they happen to make one worse.
Pancolitis dx'd 1986, full med-free remission 88-97
Flaring or simmering ever since
10 20 17.5 15 12.5 mg pred, 100 mg Imuran
Probiotics (Primal Defense and others), TSO
Turmeric/circumin, fish oil, many vits/minerals
Lower-carb version of Specific Carb Diet (SCD)