anyone respond just to rectal steroids, not oral?

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Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 11/19/2007 9:43 AM (GMT -7)   
tapering my rectal steriods, not my oral and I seem to have a few more bathroom trips and my bm's seem a little less formed.......
 
I really don't know what is helping me more the e's or the oral pred?  I believe it's the e's???  But I don't know for sure.
 
Anyone have any thoughts?
Beth, 32
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 150mg 1xday nightly;Hydrocortisone e's tapering, Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 80mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/19/2007 10:41 AM (GMT -7)   
Hi Beth,

Last year when I had my worst and longest flare ever, I eventually just tapered off the Pred because I felt that it wasn't helping. At 40 mg I was great for a couple weeks but once I got down to the 20, I was the same as I'd been. I decided that I'd tough it out and just get off the Pred anyway. Because the only other option was to raise the dose again.

Since you're taking both oral and rectal steroids, your body is absorbing a certain amount of steroids every day. Let's say it's just 10% of the rectal dose and 100% of the oral. (Not that I understand the science of this.) So if you taper either of them, you might see changes because your *overall* steroid absorption is lower.

I wonder why you wouldn't taper the oral meds before the rectal meds. That's what I would do: I would keep the rectal meds constant and taper off the Pred. I would do it that way just because I'd want to take steroids for as little time as possible and the oral meds are the stronger ones. So I'd want to see if I could get my oral Pred down and still feel decent by continuing the rectal meds.

Did your doctor suggest tapering the rectal steroids?
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 11/19/2007 11:04 AM (GMT -7)   
The only RX I respond to anymore is the enemas, with the orals I'm either allergic or non-responsive to them...I hope that doesn't happen with the enemas.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 11/19/2007 11:43 AM (GMT -7)   
Julee - I'm on the oral pred for my kidneys so, that is why I am not tapering 'yet', (sorry I did not provide that info earlier), was hoping since I was on the pred for that it would help w/my UC. I don't really think it has though. I was on the pred for a few weeks and my flare just got worse and worse and that's when I went on the steroid e's, i've been on the pred for nearly 2.5 mos now and the steroid e's for 2 mos. Was tapering every other day a week ago and this time, tried to go two days in between the taper.
Beth, 32
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 150mg 1xday nightly;Hydrocortisone e's tapering, Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 80mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 11/19/2007 11:45 AM (GMT -7)   
also Pb4, thanks for the info. I was not sure it was possible to only respond to the e's but I think that is what is happening to me too.
Beth, 32
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 150mg 1xday nightly;Hydrocortisone e's tapering, Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 80mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

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