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Red_34
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Date Joined Apr 2004
Total Posts : 23549
   Posted 11/21/2007 8:05 PM (GMT -7)   
It seems that everyone that is on 6mp here is on either 25mgs or 50mgs.  Has anyone ever been raised to a higher dose?  And has anyone ever just had variations of that dose? I went to my GI today and before I was taking 50mgs Tues, Wed, Fri, Sat, Sun and 75mgs on Mon and Thurs.  Now he wants to increase my 75mg days to 100mgs because according to my Prometheus, I'm still a bit on the low side.  Just curious what everyone else is taking in regards to 6mp and dosing.
 @--->--SHERRY--<---@
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio, Hydrocortisone enemas**Unable to tolerate Asacol, Rowasa or Canasa** 
~Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)~
~Secondary Reynauds Syndrome - '04 - Norvasc~
~Fibromyalgia - '06~
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
 
 
 
 

 
 


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 11/21/2007 10:12 PM (GMT -7)   
I'm on 100mg/day - 50mg morning and evening. Though I will also point out I have had a continuous severe flare for nearly 2 years now. Once I found my new specialist we had to hit the UC extremely hard to get any kind of improvement.
"We are dreamers, shapers, singers and makers..." - Elric, elder Technomage


Bennie
Veteran Member


Date Joined Nov 2006
Total Posts : 552
   Posted 11/21/2007 11:10 PM (GMT -7)   
Bratcat has been on 75 mg (started there). Her doctor just told us to up it to 100 mg (all her blood tests have come back fine). I'm guess it also has to do with weight (she is about 160 lbs). He wants to up it because she is lowering her prednisone. She's been on pred for quite awhile (started at 60mg) and it didn't seem to do the trick this time. She is going to 35 mg tomorrow and if she holds, she will go to 30 mg early next week.

--Mom of bratcat (16 years old)--
bratcat was diagnosed with pancolitis October 2006
Current meds:
Asacol - 4 pills/3Xday, 40 mg prednisone, 1-1/2 tabs 6-mp
 
11/14/06 - started prednisone; 1/28/07 - finished prednisone!
3/3/07 - began to taper off hydrocortisone sloowwly! Summer 2007 - slowly began tapering Rowasa. 9/07 -- flaring? Nightly Rowasa. 9/21/07 -- added hydrocortisone enemas. 9/30/07--added prednisone. 10/31--started 6-mp, stopped the enemas. Started lowering prednisone.


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 11/22/2007 4:43 AM (GMT -7)   
Thanks :) I don't think the dosage is based on weight but how well a patient metabolizes the med. I started at 25mg to be sure my body could handle it, then went to 50mgs and now I'm on the 50-100mg variation and I'm only 120lbs. I've already had 1 Initial Prometheus for baseline and 2 for metabolization (luckily my insurance pays for this!). Does anyone know what this means - my GI said "You are at the low side of the sub level). Does anyone know what the numbers mean for Prometheus metabolization?
 @--->--SHERRY--<---@
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio, Hydrocortisone enemas**Unable to tolerate Asacol, Rowasa or Canasa** 
~Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)~
~Secondary Reynauds Syndrome - '04 - Norvasc~
~Fibromyalgia - '06~
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
 
 
 
 

 
 


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/22/2007 7:29 AM (GMT -7)   
hi Red,
I just went to the Prometheus Labs website (www.prometheuslabs.com) and tried to understand the info for physicians to see if I could find an answer to your question. Well... all I could understand is this:
The 6MP test is called the Thiopurine Metabolites test. There appears to be two sets of numbers, the first tells how likely it is that the medicine is being metabolized in a reasonable amount, the second number has something to do with toxicity. I assume the second number tells you whether the drug is putting you at risk for problems. It sounds like your doctor thought the first number was low and that the second number indicated that you aren't showing any signs of the drug being toxic at the current dose.

Prometheus seems to have a decent website but it's odd that they don't have really helpful info for patients about this particular test. I wonder if you call them whether they could send you something written for patients not physcians.

I know that even when my doctor explains this stuff, I find it difficult to understand or remember later. Having something on paper would be so much nicer.

By the way-- for those who don't have the test covered by insurance -- Prometheus offers at 25% discount if you pre-pay. The form is on their website. My doctor's office didn't know about it until I told them.
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


SwollenColon
Regular Member


Date Joined Nov 2006
Total Posts : 190
   Posted 11/22/2007 9:24 AM (GMT -7)   
I'm taking 250mg azathioprine daily. I take it all at once before I go to bed. I've been on it for 12 months now, and I'm experiencing no side effects. It doesn't work near as well as I was hoping it would either.
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