Canasa suppositories?

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julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/22/2007 11:12 AM (GMT -7)   
Just out of curiosity, does anyone think the Canasa suppositories are good? My doctor thinks they are good for dealing with a flare but the last time I tried them I couldn't tell whether they were doing anything for me. One problem I had was that when you go to the bathroom in the morning, it all comes out and it's impossible to tell whether it's actually stopped the bleeding or whether it's just masked it.

Now I'm having the first signs of a flare (mucus, a tiny bit of blood) and I'm wondering whether I shouldn't give Canasa another try. It's either that or my usual Cortifoam, but I've use the Cortifoam so much in the last year that I'm trying to avoid the steroids when I can.

So.. .what's the consensus on Canasa? I want to quickly use something to stop the bleeding now before it gets out of control. I guess I could try the Canasa for a few nights and see how it goes. I'd feel better about it if someone here could tell me that it's really good for stopping bleeding.

Thanks!
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


quincy
Elite Member


Date Joined May 2003
Total Posts : 29840
   Posted 11/22/2007 11:39 AM (GMT -7)   
Hi...use them consistently....and you can also use them up to 3x daily.

Is your UC limited or throughout?

I, personally, don't think they're enough to deal with a flare...but...in saying that, if you use them early enough and consistently, they'll be of huge benefit rather than of NO benefit if you don't use them.

Have you used the 5ASA retention enemas (Rowasa) in the past? explain why not or if they worked..etc.

Be consistent in sing them and not of the idea that stopping the bleeding is stopping the flare/inflammation. It's a much more than that. I miss the point of masking symptoms...5ASA is proven to treat and maintain.

quincy
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals 
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/22/2007 12:43 PM (GMT -7)   
Thanks, Heather. My UC is limited to about the lower 15 cm. (protosigmoiditis)

about the Rowasa enemas -- yes, I've used in them in the past although it's been a few years. Generally, I tend to skip doses because I find them really uncomfortable to use. However, I know that I'm kinda just being a baby about it and that I could use them again if I really needed to. I think that's why my Dr prescribed the Canasa... because she figures I would be more likely to use them consistently. I have no problem using hte Cortifoam consistently, it's just the steroid aspect of it that's a problem. (I think the delivery system of the foam is so much easier and more comfortable. That's why I was asking a while back about the 5ASA foam that's available in Australia and Europe.)

Also-- I could never tell whether the Rowasa was really helping me which is probably also why I wasn't using it too consistently.

I think you're right that the Canasa alone wouldn't stop a flare. I start taking Tylenol w/Codeine which usually stops the D after about a week or two. It doesn't do much for the bleeding or mucus, though. I think a rectal med is really necessary for that.

What I meant about masking the symptoms was this -- If I use the Canasa, in the morning when I go to the bathroom, all I see is the medicine coming out. So if I'm having some blood, I can't see it because everything just looks like it's coated with medicine. I suppose I might notice it later in the day if there's bleeding but generally, I'm just going in the morning. Maybe I shouldn't worry about it.

In any case, it's helpful to know that the Canasa can be a good maintenance drug. Thanks for all the helpful info.
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


quincy
Elite Member


Date Joined May 2003
Total Posts : 29840
   Posted 11/22/2007 12:57 PM (GMT -7)   
Hi...the codeine is what's masking symptoms.

Use the Canasa 3 times a day....especially since you've only got 15cm inflammation.

Yes, you're making excuses. And what's worse, you're also making a decision to not use the meds properly.

What I find interesting is that you have diarrhea....to me, that says your inflammation is higher than just the 15 cm? When was your last c-scope?

The asacol comes in a foam in the UC and in Australia from what I've read....so, ask the doc for that.

The steroid topical (entocort oral and rectal) meds have about 10% absorbed into the bloodstream via the colon....so, if you're not wanting to do the steroids, make the commitment to the rectal 5ASA meds.

I think, personally, the enemas are better because of maximising the dosage into the area that tends to be the most inflamed and most stubborn, regardless of how high it goes.

I don't "like" using the rectal meds either...even after almost 19 years, I still grumble. It's not a big deal...and it's done its job considering the last c-scope.

Attitude is key, and to me since you're already on immunosuppressives, your ignoring-simple and-easy-to-use-with-least-side-effects-especially-if-you-can-use-them....can only lead you to a more intense med scenario in th future.

Sticking a med up your butt that can help is a very SMALL price to pay...if it works.

quincy


*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals 
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Post Edited (quincy) : 11/22/2007 1:04:12 PM (GMT-7)


potty girl
Veteran Member


Date Joined Dec 2006
Total Posts : 835
   Posted 11/22/2007 7:41 PM (GMT -7)   
The canasa sup. helped me alot. I went for a long time just useing asacal and thought it was working well but I always had some pain down low almost felt like it was just at the rectum area just a little pain ,started useing canasa, and it took the pain right away. I dont know if it would help higher up.
Rona

synthroid .088 mg, lowpressor 50 mg x 2, cozaar 25mg x2, imdur 30 mg
nitroquick, proventol, plavix 75 mg, protonix 40 mg x 2, asacal 400mg x 9
carafate 1 gm x 4, zyrtec 10 mg, rhinocort aqua nose spray, fish oil,
potassium.


Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4034
   Posted 11/22/2007 7:45 PM (GMT -7)   
I am curious about Canasa, too. For those that have used it, do/did you use the 500 mg or 1,000 mg?

23 years old
Diagnosed with UC March 2007
Current inflamation in the rectum
Asacol 4 tablets 3x/day
Rowasa (generic) - as needed for flares
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D) for Osteopenia; flaxseed


potty girl
Veteran Member


Date Joined Dec 2006
Total Posts : 835
   Posted 11/22/2007 10:02 PM (GMT -7)   
mine are the 1000 mg.
Rona

synthroid .088 mg, lowpressor 50 mg x 2, cozaar 25mg x2, imdur 30 mg
nitroquick, proventol, plavix 75 mg, protonix 40 mg x 2, asacal 400mg x 9
carafate 1 gm x 4, zyrtec 10 mg, rhinocort aqua nose spray, fish oil,
potassium.


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/23/2007 7:05 AM (GMT -7)   
Quincy,

I really just wanted to know whether anyone here swears by the Canasa as working. I also wanted to know how you can tell if you've stopped bleeding when all you can see is the remaining medicine in the bowl and on the toilet paper.

I found your second response less than helpful and actually I took offense at your tone. Keep in mind that you're a patient too and that you don't know everything. (As evidenced by your comment about D suggesting higher up inflammation. You can have D even if you only have proctitis. Everyone reacts differently.) Also, a lot of the people here (myself included) need encouragement and support. Statements like

"Yes, you're making excuses. And what's worse, you're also making a decision to not use the meds properly."

just comes across as unhelpful. Perhaps you typed it with a smile, but I couldn't see that.
I've been dealing with this disease for over 10 years and I've suffered plenty. I'm not "making a decision to not use the meds properly," I was just being honest about the psychological barrier I find to sticking with something that a) feels terrible and b) never seems to work anyway. I was being honest and open. I hardly need to be chatised as if I were someone you know well or as if I were your kid.

If anyone else would like to actually answer my original questions without speculating about me or my diagnosis, please do. Thanks.
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 11/23/2007 7:37 AM (GMT -7)   
Julee, I am now intolerant of Canasa but before my body decided to say Uh uh, no way, I found that Canasa did help control my more worse rectal inflammations. It helped stopped the bleeding from what I can see - but you're right, if you can't see it because of what comes out then how are you to know right? If you are curious as to if you are still bleeding or not, the next time you go to your doc, you can request a fecal occult (?) test. But, I say give it a go but only give a few days to see if it's going to control your possible impending flare. If you still see blood after a few days, then it might be wise to start back on the foam. Oh and when I was flaring pretty bad while on Canasa - when I would go to the bathroom, the stuff that comes out from the Canasa was tinged with red because of the bleeding but with minor bleeding that might not be so evident.
 @--->--SHERRY--<---@
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio, Hydrocortisone enemas**Unable to tolerate Asacol, Rowasa or Canasa** 
~Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)~
~Secondary Reynauds Syndrome - '04 - Norvasc~
~Fibromyalgia - '06~
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
 
 
 
 

 
 


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/23/2007 8:03 AM (GMT -7)   
Thanks, Red. The test at the doctor is a good idea. And trying it for a few days seems like the way to go. From past experience, I know that I only have a fairly small window of time to get this under control. I've been able to quell 3 mini-flares this year, so I'm optimistic that I can do it... although, still nervous as usual. It would be great to be able to get the bleeding to stop without the Cortifoam. Thanks.
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


quincy
Elite Member


Date Joined May 2003
Total Posts : 29840
   Posted 11/23/2007 11:59 AM (GMT -7)   
I apologise for the forwardness, and it's understandable you took offense.....

The doctors do prescribe Canasa as a treatment and maintenance...but the patient has to use the meds consistently. I don't see them as being as effective as in the enema form...but the alternative you're interested in should at least be investigated.

You know that they're working if your symptoms are improving. If you're having others bms during the day and you have no bleeding, you're improving. You'll also know by the kind of bms you have and whether there's mucus, straining..etc. If that's improving..it's working.

You're on codeine, that will slow down the colon and the activity, so the above suggestion may be moot except for the bleeding/non-bleeding.

The fact that you have diarrhea would suggest something else is going on....and it's possible that inflammation is higher in the rectum ...yes, proctitis can be anywhere the length of the rectum and leading up into the sigmoid...so, there's length to create different symptoms.
I didn't say it was, for how would I know....just to state it's a possibility. It's also not unheard of that UC spreads. Hence the question as to when your last c-scope was.

I still strongly suggest you use 5ASA rectal meds consistently since you're not wanting to use steroids....it just takes a bit longer for the lessening of symptoms to be noticed.

You're right, I don't know everything....but I DO know rectal meds and have never been on steroids to deal with flares in well over 18 years. Your UC is prime for that type of treatment...if you give it a chance. if you have no side effects from them....that's a huge kudo.
Your mini flares may just be a continuing slow simmer of inflammation that's not being dealt with long enough...for the cessation of bleeding shouldn't mean all is OK.

quincy
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals 
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5135
   Posted 11/24/2007 4:49 PM (GMT -7)   
I have doubts as to whether Canasa does anything besides ooze greasy ick out one's anus a couple hrs after insertion! That's a reason for using Rowasa instead-- AND, it reaches the sigmoid, too. My gastro told me that some patients say they use an Anusol to push the Canasa up higher-- so that it won't ooze out. I would go for the Cortifoam, Julee70-- since it always helps you quickly + it's only 10% steroid to boot. pb4 would likely agree with this, having used Cortifoam w/o problems many times. We need that blasted 5-ASA foam in the U.S.!!!!!!!! Why don't the pharmaceuticals listen to us on this issue? / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])




.

Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5135
   Posted 11/24/2007 4:53 PM (GMT -7)   
P.S. re Sara14's Q on Canasa's dosage: THEREAREMIRACLES reported a while back that she could only get 1000 mg Canasa. She was told that the 500 mg had been discontinued. / Old Hat

potty girl
Veteran Member


Date Joined Dec 2006
Total Posts : 835
   Posted 11/24/2007 4:56 PM (GMT -7)   
I never have a problem with them oozeing out.
Rona

synthroid .088 mg, lowpressor 50 mg x 2, cozaar 25mg x2, imdur 30 mg
nitroquick, proventol, plavix 75 mg, protonix 40 mg x 2, asacal 400mg x 9
carafate 1 gm x 4, zyrtec 10 mg, rhinocort aqua nose spray, fish oil,
potassium.


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/24/2007 8:39 PM (GMT -7)   
I haven't had a problem with them oozing out either. But here's my recent experience: I used Canasa twice with no benefit the next days. In fact, yesterday I was bleeding a lot more with the added new symptom of running to the bathroom a bunch of times. What fun.

This morning, since I knew I had to be out of the house all day, I used a half a dose of Cortifoam. And I've felt great all day. Haven't run to the bathroom once.

Ok, so now I'm going to try Canasa at night (to be sure about the no oozing) and half a dose of Cortifoam in the morning. Maybe that's the magic combo for me. Plus, with the half dose, it's only 5% of the steroid absorption and 100% of the psychological benefit of believing it works. :) Thanks, Old Hat, for your helpful comments. I really am going to work on lobbying for the 5ASA foam soon... really I am.


P.S. Many thanks to Quincy for clarifying our misunderstanding. I really appreciate all the great info/advice/support here from everyone.
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


quincy
Elite Member


Date Joined May 2003
Total Posts : 29840
   Posted 11/24/2007 8:54 PM (GMT -7)   
Using meds in conjunction with one another is the way to make them work for you. Lots of trial and error and it seems you've found a good combo.

I think you eventually should try the Rowasa again, however.....for many of us it can take a while for them to work. Although, they don't work for everyone. Consistency in using them is the only way to know for sure.

Keep us posted...

quincy
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals 
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

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