Why do you take azathioprine at night?

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Regular Member

Date Joined Jan 2004
Total Posts : 40
   Posted 11/24/2007 4:39 PM (GMT -6)   
I noticed most people on here say they take aza at the same time every night, usually close to bed time.  I just started the stuff and my GI didn't say anything about when to take it and I'm just wondering why most people say bed time.

Veteran Member

Date Joined Jan 2006
Total Posts : 616
   Posted 11/24/2007 4:47 PM (GMT -6)   
I think it causes some people fatigue. I used to take mine in the morning and it didn't seem to be a problem.
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Veteran Member

Date Joined Dec 2005
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   Posted 11/24/2007 5:14 PM (GMT -6)   
It makes me a little nauseous. I eat dinner and then take it. Imuran builds up in our bodies so I don't think it matters when we take it.
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-6 a day, Acidopholis Pearls, Prilosec OTC

Co-Moderator UC Forum

New Member

Date Joined Nov 2007
Total Posts : 17
   Posted 11/24/2007 5:29 PM (GMT -6)   
I take mine in the morning with my breakfast.  It has never bothered my stomach or caused fatigue like some seem to get.  Probably just what works best for the individual.

Regular Member

Date Joined Jul 2007
Total Posts : 77
   Posted 11/24/2007 8:25 PM (GMT -6)   
I take mine at night, I just started two weeks ago, I tried nighttime because I was worried about nausea, but I am feeling really groggy in the morning and basically throughout the next day.

I just feel in a fuzz. It's really not cool. Any suggestions?

Veteran Member

Date Joined Sep 2005
Total Posts : 698
   Posted 11/25/2007 1:16 PM (GMT -6)   
Unfortunately I was one of the minority that cannot take azathioprine. It raised my pancreas enzyme levels to over 1500 (normal is no more then about 300 or so) and i puked and shook from acute pancreatitus and was in intense pain for 4 days, barely able to keep water down. I was so dehydrated that my hands started to cramp up.

for me, never again.
34 year old Male
First Flare was February 2005. Diagnosed June 2005-left-sided Colitis, suspect it has since spread. Started 4000 mg Oral Salofalk June 2005-stopped January 2007. Remission until November 2006.
Been in a flare to various degrees since November 2006 to February 2007. Currently in remission.
Presently on 0 mg Prednisone-down from 60 mg!
Weekly 4000 mg Salofalk enemas.
Daily 4000 mg Salofalk oral.
Started Omeprazole 20 mg February 2007.
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Regular Member

Date Joined Sep 2006
Total Posts : 133
   Posted 11/25/2007 6:23 PM (GMT -6)   

  I feel kind of silly because I haven't been reading this forum lately (I've been busy) and now that I did, it just validated what's been going on with me and Imuran.  I started it like 2 weeks ago and I have been experiencing the same signs/symptoms people are talking about.  I have been really nauseous and ust recently very tired.  It took me a while to narrow it to the Imuran but I started taking it at bed or with a glass of milk and it seems better.  I should always know just to come here first! :)


29 years old; diagnosed since 1997 (but I've had it forever)
Current meds:
-I was awaiting a Humira study.  Now, ironically, they say I'm "too well" for the study now! :(
-Prednisone starting at 40 mg.  I'm at 20 now.
-Asacol 12/day
-Failed Remicade (8/06-8/07)
-Calcium (for my steroid-affected bones)
-Prenatal vitamins (for the extra stuff, not for pregnancy)
-B vitamin complex
-Miralax (because surprisingly I need it sometimes)

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 11/25/2007 7:21 PM (GMT -6)   
I was not told any specific time to take it either. I take it at night as I was foggy in the am and I think it helps me sleep. Though lately I can sleep 10 hours and still be tired and I'm on approx 50mg of pred a day.....
Beth, 32
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 200mg 1xday nightly;Hydrocortisone e's tapering, Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

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