Posted 12/3/2007 11:32 PM (GMT -6)
Hey Eva Lou!

I've been on the UC Abatacept trial since August 2007. My Gastro specialist thinks I copped the placebo first off. I was taken off the "unknown trial dose" at the end of July 2007 and have been recieving the real "open label" stuff since then.

It took 5 infusions for it to take noticable effect. I find it kicks in exactly 14 days after the injection and the effects last between 2 and 3 weeks before things start to fall off again.

Abatacept has been great as I have been able to drop from 50mg of pred in July to 2mg of pred at present.

The people in the trial I know who have CD appear to get effect faster then the UC people in our group.
"We are dreamers, shapers, singers and makers..." - Elric, elder Technomage

Post Edited (Severin) : 12/3/2007 9:40:06 PM (GMT-7)

Posted 12/4/2007 12:06 PM (GMT -6)
well thanks for the info, guys- I have no intention of trying to get into the study, as the Remicade has been working pretty well for me. But I am always interested in hearing about new meds, & how people do on them. Is it a biologic? Those drugs have really taken off in the past year or so- they seem to me to be the wave of the future as far as treating Crohns/UC.

diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day
Prednisone- 15mgs/day
 

Posted 12/4/2007 9:43 PM (GMT -6)
Both Remicade and Abatacept are biologics but they act differently. Remicade is a TNF blocker and Abatacept acts on T cells. Abatacept is a good alternative for people that don’t respond to TNF blockers such as Remicade or Humira. After using Remicade I was tested for antibodies and none were found. That meant that other TNF blockers probably wouldn’t work and that is why I went for an Abatacept trial instead of a Humira trial.
Paul
Diagnosed in 2000 at age 43 with UC extending half way across transverse colon.
Allergic reaction to Asacol, Pentasa and Dipentum - can’t take any more 5ASAs.
Prednisone - worked well for 1 month, then side effects became unbearable.
6-MP - blood tests showed not metabolizing properly.
Corticosteroid enema, Flagyl, Ciprofloxin, VSL#3, Adacolumn Apheresis – no effect
Methotrexate with Remicade - 7 infusions with no improvement
Folic Acid and B12 injections.
Currently in Abatacept trial - waiting for remision
 

Posted 12/4/2007 9:54 PM (GMT -6)
I just want to say I admire anyone who takes part in a clinical trial! Your participation is vital to the advancement of new medications. It is a big commitment and it's great for the rest of us. Thank you!

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