Question about Colazal

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Annie76
Regular Member


Date Joined Jul 2007
Total Posts : 66
   Posted 11/29/2007 9:21 PM (GMT -7)   
I have been on Asacol/Rowasa for 11 years. They are no longer working for me. At my last GI visit he felt I should go on Imuran. He asked me to go home and think about it. If I had any further questions I was to make another appointment with him. Well, I made another appointment today but can't get in until Dec. 19th. Some very helpful people on this forum have suggested I try Colazal and possibly the steroid enemas. It has been suggested that Colazal might be more effective than Asacol for my type of UC. I should also note that I tried Lialda for a month and got worse. I guess I am just trying to be thorough before moving on to the heavy drugs. Are there any specific questions I should ask my GI? Do any of you feel this is worth a try or should I cut my losses and move on? He told me that 85% of his UC patients respond well to the 5-ASA drugs. Makes ya feel like a loser.
left-sided colitis diagnosed after 3rd pregnancy 11 years ago: was in remission for 5 years
Current UC Meds:  12 Asacol per day
                          1 Rowasa enema at night
 
Other Meds:  Lipitor, Multi-vitamin, asadophilus, cinnamon capsules
 
In a flare since the middle of April


Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4034
   Posted 11/29/2007 9:40 PM (GMT -7)   
If it was me, I would try the Colazal and steroid enemas before moving on to the "harder" drugs, like imuran.
23 years old
Diagnosed with UC March 2007
Current inflamation in the rectum
Asacol 4 tablets 3x/day
Rowasa (generic) - as needed for flares
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D) for Osteopenia; flaxseed


quincy
Elite Member


Date Joined May 2003
Total Posts : 29848
   Posted 11/30/2007 12:45 AM (GMT -7)   
You're not a loser Annie...and there are many who have made the switch to Colazal and did much better. If they work in conjunction with the steroid enemas...then that's worth it....you have nothing to lose by trying.

Just ask the doc how long you are to use them before considering the immuno-meds.

Keep us posted.
quincy
*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals 
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 11/30/2007 4:59 AM (GMT -7)   
Annie, your story sounds exactly like mine. I was on Asacol for years when it stopped working for me. So my GI switched me to Colazal and boy did that make a world of difference! Definately ask to switch to this in addition to the steroid enemas before resorting to an immune suppressor. I was on Colazal only for about a year (in remission) when I got thrown into a flare, had to go on steroid enemas, became steroid dependant because I would flare horribly every time I went off the enemas, and it was only then that I went onto 6mp. But if you can stop your flares with as little as med or potent meds as possible; go for it!
 @--->--SHERRY--<---@
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio, Colocort**Unable to tolerate Asacol, Rowasa or Canasa** 
~Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)~
~Secondary Reynauds Syndrome - '04 - Norvasc~
~Fibromyalgia - '06~
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
 
 
 
 

 
 


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 11/30/2007 7:12 AM (GMT -7)   
Sounds very reasonable to try another 5ASA drug first. You could ask your doctor to describe the other 5ASA drug choices and to choose the one that might be best for you. There are others besides Colazal and they are all slightly different from one another.

I was also on Asacol and then it stopped working. I think I had a few decent months with Colazal but then went on to Pentasa and DiPentum. (No one mentions those other two 5ASA drugs here... maybe they aren't used anymore?) By the time I got to making the choice for 6MP, it was an easy one. There was nothing left to try!

It's definitely worth a shot. If you can give Colazal or a different 5ASA a month or two as a test, that would be great.

By the way -- about the 85% of patients responding... I've read a study that said that most patients respond better to the 5ASA if used in conjunction with Rowasa or another rectal med. Kind of makes you wonder about that 85% comment. If patients are using both, who's to know which element is the most helpful? Hm...
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


Annie76
Regular Member


Date Joined Jul 2007
Total Posts : 66
   Posted 11/30/2007 8:10 AM (GMT -7)   
Thanks for validating my thought process. I want to do everything possible before I move to Imuran. I want to be able to intelligently discuss this with my GI. He is usually very good about letting me try things. I do have a question about the steroid enemas. Some have said they use the Rowasa at night and the steroid in the morning. If I may be so bold, how do you retain the morning enema if you are up and moving around? Also, how long are you on this enema and do you get the side effects associated with steroids?
left-sided colitis diagnosed after 3rd pregnancy 11 years ago: was in remission for 5 years
Current UC Meds:  12 Asacol per day
                          1 Rowasa enema at night
 
Other Meds:  Lipitor, Multi-vitamin, asadophilus, cinnamon capsules
 
In a flare since the middle of April


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5135
   Posted 11/30/2007 8:25 AM (GMT -7)   
I'd recommend trying Cortenemas for at least 3 weeks. However, it does take a longer period of use for them to be effective if one has inflammation in the descending colon-- where the systemic chemistry has to kick in. In my experience, one can use them for 3 months w/o major side effects cropping up, except for increased appetite & some thinning of scalp hair. That being said, let me move on to the 5-ASAs. Pentasa is mainly for patients with right-sided inflammation because it starts acting in the terminal ileum. Dipentum can reduce inflammation, but prolongs D-- my gastro admitted that after Colazal came on the market. I myself have done better on Colazal than with any of the other older 5-ASAs, including Rowasa! Therefore, I would recommend that you try Colazal before giving up on 5-ASAs entirely. Ask your doctor what he thinks about possibility of using Cortenemas alone for up to 4 weeks & then phasing in Colazal gradually. My feeling about drug combos is that they make it harder to tell where side effects are coming from-- so better to do one type of drug at a time (initially) to determine which are ineffective or cause major adverse reactions. / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily; seem to be back in remission)                                                P.S. Your doctor may want to avoid prescribing steroids if you are middle-aged, due to potential for bone loss.

Post Edited (Old Hat) : 11/30/2007 8:24:59 AM (GMT-7)


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5135
   Posted 11/30/2007 9:09 AM (GMT -7)   
Annie76-- I bumped over the online article reference for current IBD medical treatment options so that you can have a look. The 1st part deals with UC & covers non-response to 5-ASA meds, in addition to listing the differences between types of 5-ASAs. / Old Hat

barbl
Regular Member


Date Joined Jul 2006
Total Posts : 320
   Posted 11/30/2007 3:19 PM (GMT -7)   
I had always used Sulphasalazine, it stopped working. I got a script for Lialda, I got consistently worse and ended up in the E.R. with dehydration from all the "D and blood loss. Fired the old G.I. (satan devil ) and the new one put me on a low dose of Pred and 9 Colazal, it started working within days. That was back in September. Best thing I have done yeah
Dx'D in 1990. Remission 1991 - 1/2005
Both flares were in extremely stressful times in my life
Colonoscopy 10/2005 80% of Colon diseased, or as I like to say "Intestinely challenged"
*****9/2007 dumped my GI who I refer to as "Satan" New GI, new med TOTAL remission with in 2 weeks.
Colazal 9 capsules a day*****


kazygirl
Veteran Member


Date Joined Sep 2007
Total Posts : 955
   Posted 12/3/2007 2:27 AM (GMT -7)   
i read that you can only be on colazal for 12 weeks.
whats the deal with these drugs saying you can only use them for so long but we have to be on them for years?
how can that be good?

im curious about colazal. im over in australia and dont really know about it.
ive been on mesalamine for over a year now and im still flaring, so i dont know if its working for me or not.
plus i have diarrhea this whole time too so i dont know if its the uc or the meds?

what is colazal exactly?
is it like my mesalazine? (salofalk)
steph - 31 year old female - diagnosed UC in 2000
started as proctitis and now is pancolitis..this year long flare is now severe on left side only to splenic flexure. 
50mg prednisone 1x day with breakfast 5 weeks now.. will taper next week by 10mg every 5 days.
2x 500mg mesalazine 2x morning & night - colifoam enima 1x at night - 1/2 endone every 6 hours for pain
now taking calcium supps for pred side effects - got lots of those!
50mg imuran 1x day 8pm to have a baby - VSL#3 didnt work - Aloe Elite didnt work - Budesonide didnt work
ive lost 40+lbs and my legs look like sticks ... ewww
 
 


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 12/3/2007 4:52 AM (GMT -7)   
Colazal is a basalazide. It's still a 5-ASA but it breaks down differently in the colon and under different PH levels (I think). But the directions for 12 weeks don't apply to us, that is for other forms of colitis - not UC.
 @--->--SHERRY--<---@
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio, Colocort**Unable to tolerate Asacol, Rowasa or Canasa** 
~Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)~
~Secondary Reynauds Syndrome - '04 - Norvasc~
~Fibromyalgia - '06~
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
 
 
 
 

 
 


Rio in Maryland
Veteran Member


Date Joined Nov 2007
Total Posts : 891
   Posted 12/3/2007 6:15 AM (GMT -7)   

I recently switched to Colazal. 

The directions for 12 weeks that you've mentioned may be due to a a disclosure by the manufacturer that "the safety and effectivess of colazal beyond 12 weeks in adults have not been established (beyond 8 weeks in children)".


Rio, 31 yr old male - diagnosed with UC in 07/2006.
 
Alternative therapies for several months (SCD, ayurvedic treatment, VSL#3): didn't work and became anaemic. Canasa, 2 daily: remission for a month then flared-up.
07/07-11/07: 4800mg Asacol (6 x 400mg, twice a day) & Aloe Elite.
Completed first (6 week) tapered course of Pred in 10/07, flaring up since coming off it.
Currently on: 12 x 750mg Colazal, Cortifoam once a day, Nature's Way Probiotic twice a day. 
Diet: Cut out caffeine and alcohol after diagnosis.  Been vegetarian for many years.  Low dairy, low carb, and avoiding foods that are processed, fried, spicy, acid forming, fungal, contain yeast (i.e. I don't have a life, but desperate times call for desperate measures!).


Annie76
Regular Member


Date Joined Jul 2007
Total Posts : 66
   Posted 12/3/2007 8:29 AM (GMT -7)   
Is Colazal better for those of us with left-sided UC because it dissolves further down in the colon? Is that part of why the Asacol is no longer working for me? If so, why when I tried Lialda, I got worse?
left-sided colitis diagnosed after 3rd pregnancy 11 years ago: was in remission for 5 years
Current UC Meds:  12 Asacol per day
                          1 Rowasa enema at night
 
Other Meds:  Lipitor, Multi-vitamin, asadophilus, cinnamon capsules
 
In a flare since the middle of April


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 12/3/2007 9:03 AM (GMT -7)   
My GI told me that yes, Colazal can be better for left sided because of where and how it dissolves. He mentioned that sometimes Asacol will not break down properly and allow the med to reach the desired spot in left sided. I'm not sure what the chemical make up of Lialda is but it is similiar to Asacol so that could be why you haven't responded well to Asacol or Lialda.
 @--->--SHERRY--<---@
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio, Colocort**Unable to tolerate Asacol, Rowasa or Canasa** 
~Allergies - Singulair, Astelin(got the script - just haven't tried it yet!)~
~Secondary Reynauds Syndrome - '04 - Norvasc~
~Fibromyalgia - '06~
@--->--Moderator for Allergies/Asthma and Co-moderator for UC--<---@
PLEASE HELP HEALINGWELL CONTINUE TO HELP OTHERS BY CLICKING HERE: DONATE
 
 
 
 

 
 

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