I've tried Sulphasalazine, Colazal, and Lialda and I think they work to reduce the inflammation, but they also cause bad diarrhea. Has this happened to anyone else? I've thought about taking an anti-diarrhea medicine at the same time, but I don't know if that's advisable. I am not crazy about the alternative to these drugs which appears to be 6-MP. My reaction to the above drugs seems to be very unusual.