Imuran Side Effect

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Bmshurt
Regular Member


Date Joined Oct 2007
Total Posts : 28
   Posted 12/10/2007 5:19 PM (GMT -7)   
Doctor started me on Imuran after last flare up and was on it for 2 weeks then got some extreme abdominal pain. Was unable to take the pain so I went to the ER (wife had to drive me in, was barely able to walk). Had cat scan and ultra sound done on me and they determined that my Pancreas was inflammed caused by the Imuran.  Painful experience but at least they figured it out. Needless to say im not taking Imuran any longer and will be going back to Asacol starting next week.
Medication:
Prednisone 20MG Daily
Imuran x1 Daily
Probiotic x2 Daily
Multivitamin x1 Daily
Oscal Calcuim Tabs X2 Daily
Fish Oil x2 Daily
 
Diagnosed with UC in May of 2007
 


tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 12/10/2007 6:40 PM (GMT -7)   
Oh no! How scary! Can you take 6mp? Or do they think it would cause the same thing?
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium

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Co-Moderator UC Forum


betsaronie
Regular Member


Date Joined Oct 2007
Total Posts : 318
   Posted 12/10/2007 7:50 PM (GMT -7)   
i would think that 6mp would cause the same reaction since they are similar drugs. I can't take Imuran because my pancreas became inflammed from 6mp. its a nasty hurt, glad your ok!
diagnosed Dec 2006 at 22 years old and flaring since
30mg prednisone in a 4 week taper
1000mg of Curcumin twice a day
probiotics
fish oil-3
coral calcium
multivitamin
yellowdock
iron
allergic or intolerant to all 5ASAs and 6-mp


superdeejayanna
Regular Member


Date Joined Jul 2007
Total Posts : 77
   Posted 12/10/2007 8:43 PM (GMT -7)   
Oh scary! I've been having bad vomiting and aches and they thought it was pancreas, today my bloodwork comes back and it turns out it's my liver, inflamed by the Imuran, so I'm off that as well!

cap'n colitis
Regular Member


Date Joined Nov 2007
Total Posts : 51
   Posted 12/10/2007 9:57 PM (GMT -7)   
These stories scare the crap outta me. I just started Imuran about a month and a half ago, and I was/am sooooo cautious about it. I started feeling very very slight twinges of something in my upper left abdomen that I hadn't had before...It wasn't sudden or severe. It wasn't even bothersome, except that I noticed "something" no matter how slight. So I called my doc, and he had me go in for a full blood panel and thankfully everything came back ok. I know pancreatitis comes on very suddenly and severely, but still I was just paranoid about this med. For what it's worth, it seems to be helping. I just hope I don't run into the same problems that you good folks have. What a nightmare!! I'm still a little freaked about bein on this med!
Male - Age 39
Diagnosed in 1988
Moderate Pan Colitis 10 years ago, but mild and fairly controlled since then
40mg Pred 30mg Pred 25mg Pred 20mg 15mg 10mg 5mg  0mg Pred
100mg Azathioprene
800mg Asacol 2x daily
20mg Omeprazole
 
 
 
 


Another UC wife
Veteran Member


Date Joined Jun 2007
Total Posts : 2111
   Posted 12/10/2007 10:57 PM (GMT -7)   
I had a number of questions for the doctor at Mayo recently and he knew that they were motivated by my concern about the imuran my husband is on. He told us to please not be so overly concerned about that particular drug - he said it is a safe drug if you are not experiencing any ill effects from it and he requires a blood test (3 different ones) every single month before he will write a prescription for another 30 days.

He is monitoring and watching very closely for the first year. As long as things are going as they have been then after the year then maybe the blood work is every 3,4 or 6 months??? Didn't ask about that as we have a good 10 more months to go on the monthly monitoring.

That being said - if that drug is helping you and you are being monitored then it is obviously something that works and helps you. But for those above who had such a bad reaction to the drug that is a real shame you had to go through that. Hopefully the next drug will work much better and offer some relief.

61 yr old male~Colitis 1st diagnosed Jan '05-cleared up within a few wks. Flared again in May '06 (now UC) & hospitalized 5/07-currently heading towards a remission. Osteopena of spine from prednisone DX 8/07  Oct 07 feeling quite normal most days.  150mg Imuran 2 1/2 mg prednisone & tapering, 12 Asacol, Lidocaine Hydrochloride Jelly 2%,multi vitamin, iron 1X day, DanActive, chewable calcium, Prilosec 20mg, enalapril 10mg, glipizide 5 mg, zocor 40 mg, baby aspirin, (Fentanyl pain patch 50mg 72 hrs  Morphine Sulf 15 mg twice daily)Cortifoam enema PM, Canasa suppositiry AM, folic acid 1mg, Fosamax 1x month


MitzMN
Veteran Member


Date Joined Feb 2007
Total Posts : 622
   Posted 12/11/2007 7:42 AM (GMT -7)   
Let me echo what Another UC wife has said. Reading the side effects and even hearing that this drug is an immunosuppressive scares the crap (sorry for the pun) out of folks. I wish they would relabel it, call it something different, and not scare folks so much about it. I was so afraid to go on this drug, but I've noticed no side effects and my colitis is kept in such great control with it (except for minor flares, which are easily brought under control with enemas).

I've been on this drug for six years. It's been a wonder drug for me. Please don't imagine problems. It's always good to be safe, but don't worry so much about it, is my advice!

Mitz
Sporadic proctitis since about 1985. Mother had J-pouch surgery 1983.
DX'd with clostridium difficile in 2000. Pred, two courses of Flagyl, then Vancomycin finally got rid of it. 2001 colonoscopy dx'd left-sided UC. . Treated with prednisone, Rowasa, Asacol. Asacol not working, switched to Imuran. Three small flares since in 2002, 2005, and 2007, brought under control with steroid and Rowasa enemas. Lap Chole performed October 26, 2007, after gall bladder attack in June, '07.
Daily meds: 100 mg Azathioprine and 225 mg Effexor XR (for chronic, longstanding depression), many vitamins and Primadophilus Reuteri


cap'n colitis
Regular Member


Date Joined Nov 2007
Total Posts : 51
   Posted 12/11/2007 9:00 AM (GMT -7)   
Thanks for the words of encouragement! I'm feeling like Imuran is more my friend every day. Esp since the mild hairloss side-effect is starting to go away too (the least of my concerns).. I think that my body is starting to adapt to it.

Male - Age 39
Diagnosed in 1988
Moderate Pan Colitis 10 years ago, but mild and fairly controlled since then
40mg Pred 30mg Pred 25mg Pred 20mg 15mg 10mg 5mg  0mg Pred
100mg Azathioprene
800mg Asacol 2x daily
20mg Omeprazole
 
 
 
 


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 12/11/2007 9:49 AM (GMT -7)   
Bm's how long were you on Imuran for?

I worry about the side effects too. My next step is remicade if Imuran fails and then I fear what if I can't take that for some reason.....etc. (I know it's not good to think like that but it's hard not to).
Beth, 32
Major Flare Sept/Oct 07 ~ working on remission almost there
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 200mg 1xday nightly;Hydrocortisone e's tapering, Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

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