Interesting Article RE: enzyme in gut

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doors12
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Date Joined Jul 2006
Total Posts : 636
   Posted 12/13/2007 8:09 PM (GMT -7)   
 
 
Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Pancolitis (Mild to Moderate)
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo
In remission about 2-3 months after E.R. but not back to normal!
 
~Interested in finding a cure/making sense out of U.C. and philosophical and psychological aspects of UC and "Stress" and Personal Development issues with Chronic Illnesses. 


pb4
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Date Joined Feb 2004
Total Posts : 20577
   Posted 12/13/2007 8:38 PM (GMT -7)   
Ya this is a good link (I had to copy and paste it), one of the members at the crohns forum made mention to this today as well.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


DanthaMan
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Date Joined May 2005
Total Posts : 495
   Posted 12/13/2007 8:42 PM (GMT -7)   
Thats really interesting. Intestinal alkaline phosphatase might be that "peacemaker" that we are all missing. Somebody posted a link on here not to long ago about a defect in our gut. If I remember correctly, we have peacemaker cells that keep things in order. They say that intestinal alkaline phosphatase is an enzyme, but maybe that are produced by the peacemakers cells, which are defective?

Reading wiki about Lipopolysaccharide's, it says they produce pro-inflammatory cytokines, which leads to inflammation.

Maybe they are on to something here.

DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 12/13/2007 8:57 PM (GMT -7)   
It looks like naringin, which comes from grapefuit, inhibits lipopolysaccharide (LPS).

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-4H0S7BH-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=aac721c8a949053fa07c5c98c035a2e9


Thanks again for the link.

doors12
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Date Joined Jul 2006
Total Posts : 636
   Posted Yesterday 10:17 PM (GMT -7)   
I wiki'd Zebrafish and was surprised to find they are common aquarium fish. I think I may have even had some of them in an aquarium I had in college. Strange, maybe the little buggers end up solving the whole DD
Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Pancolitis (Mild to Moderate)
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo
In remission about 2-3 months after E.R. but not back to normal!
 
~Interested in finding a cure/making sense out of U.C. and philosophical and psychological aspects of UC and "Stress" and Personal Development issues with Chronic Illnesses. 


Old Mike
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Date Joined Jan 2007
Total Posts : 3790
   Posted 12/17/2007 8:59 AM (GMT -7)   

Here is a interesting UC alkaline phosphatase trial, it works, too bad it needs to be enteric coated. Old Mike

Copy and paste the link, Liks dont seem to be working right for some reason.

 


Post Edited (Old Mike) : 12/17/2007 9:05:55 AM (GMT-7)


DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 12/17/2007 9:56 AM (GMT -7)   
http://cat.inist.fr/?aModele=afficheN&cpsidt=15932534

Dont understand half of what they are saying!

DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 12/23/2007 11:25 AM (GMT -7)   
anyone going to try anything with this study?

DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 12/24/2007 6:46 PM (GMT -7)   
http://dissertations.ub.rug.nl/FILES/faculties/science/2007/a.tuin/c6.pdf

doors12
Veteran Member


Date Joined Jul 2006
Total Posts : 636
   Posted 12/25/2007 11:44 AM (GMT -7)   
Good find on the above article.
 
 
I invest in stocks and have been looking for a way to play this.  The company that comes up with this is "AM Pharma."  They are in another country and I haven't the foggiest clue how to invest in them.  Except that a London company, BBI Holdings, apparently has a subsidiary that owns 8% of AM Pharma.  Then I found out that an American company, Inverness , stock ticker IMA is seeking to buy BBI Holdings.  But IMA has been doing nothing but acquiring companies lately.  Ironically enough, after having taken the back door into this research, I find out Cramer likes IMA and I found a video of him referring to his stockpickr website that states George Soros has IMA in his portfolio.
 
This is not my field of expertise.  I would assume if this led to a novel treatment, whoever held the patent, whoever supplied the materials etc would profit.  Sometimes that is just hard to figure out. 
 
Sorry as this is slightly off-topic; I just couldn't resist sharing this information I spent hours researching with you guys.  I obviously see huge potential in any company that can more effectively alleviate the suffering that not just us, but folks with many autoimmune conditions go through. 
 
Let me know if anyone is interested in pursuing this investment research.
 
Merry Christmas to All
 
Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Pancolitis (Mild to Moderate)
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo
In remission about 2-3 months after E.R. but not back to normal!
 
~Interested in finding a cure/making sense out of U.C. and philosophical and psychological aspects of UC and "Stress" and Personal Development issues with Chronic Illnesses. 


DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 1/1/2008 9:47 AM (GMT -7)   
Another Link:

http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijge/vol4n1/lps.xml

I think this study is really important. It shows that the immune system is "attacking" itself, but not for the reasons western medicine says. It is attacking itself because the immune system has been compromised by LPS. LPS uses the body's first line of defense, the mast cell to help them attach to our intestinal mucosa barrier. Once the barrier is disrupted, particles of food, bacteria, etc are all introduced to the body through holes in the gut mucosa. The immune system sees all these as foreign and induces inflammation.

Its a cheesy summary, but I thought I would try and paint a picture. This looks like a cycle to me, with the LPS initiating and perpetuating the situation. The reason it can perpetuate the situation is inflammation alters your bodies ability to produce IAP. I wonder if this might be one of the genetic problems, the ability to produce sufficient IAP.

Post Edited (DanthaMan) : 1/1/2008 10:54:01 AM (GMT-7)


DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 1/3/2008 1:20 PM (GMT -7)   
I got the Swanson supplement of naringin yesterday. THe bottle says to take 1-2 capsules twice a day. I am going to take 2 three times a day and see if I get any results. Already I am feeling
better, but I am just getting over being sick, so that might be why.

Will keep everyone posted.

doors12
Veteran Member


Date Joined Jul 2006
Total Posts : 636
   Posted 1/4/2008 8:26 PM (GMT -7)   
Definitely keep us posted, Dantha.

I Didn't know there was a supplement for that -
One point of caution? I don't know if it's the same as grapefruits, but I've heard grapefruit can interact with some medicines, I believe it increases the amount of medication (some medications at least) in the blood. If anyone knows the details, feel free to chime in

GL
Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Pancolitis (Mild to Moderate)
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo
In remission about 2-3 months after E.R. but not back to normal!
 
~Interested in finding a cure/making sense out of U.C. and philosophical and psychological aspects of UC and "Stress" and Personal Development issues with Chronic Illnesses. 

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