uc different from cd

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Regular Member

Date Joined Nov 2007
Total Posts : 401
   Posted 12/20/2007 8:31 PM (GMT -6)   
is their a difference in the genetic make-up between these 2 diseases that shows on pathology/biopsy?
Mom to 19 year old daughter diagnosed 11/07.

Veteran Member

Date Joined Aug 2007
Total Posts : 2204
   Posted 12/20/2007 9:17 PM (GMT -6)   
The difference is usually in the pattern and location of inflammation. UC commonly has a solid area of inflammation, usually starting on the left side of the colon and working its way around, depending on severity. Crohn's has patchy inflammation and, as I understand it, is most often found in the small intestine, near where it attaches to the colon, but can actually strike just about anywhere in the digestive tract. When it appears in the colon, it's called Crohn's colitis to differentiate from UC.
Diagnosed with ulcerative colitis spring 1999
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal.

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 12/20/2007 9:52 PM (GMT -6)   
Also, microscopically Cd damage appears deeper in the intestine lining. Uc only affects the mucousal layer of the intestine.
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Elite Member

Date Joined Feb 2004
Total Posts : 20577
   Posted 12/20/2007 10:11 PM (GMT -6)   
Yes, genetically different, there have been many more genes located regarding crohns than UC, but I'm unsure if it shows up on pathology/biopsie...Though there are tests that show markers for crohns...I just don't know how reliable it really is, prometheus tests.


My bum is broken....there's a big crack down the middle of it!  LOL  :)

Elite Member

Date Joined Feb 2004
Total Posts : 20577
   Posted 12/20/2007 10:15 PM (GMT -6)   
CD can affect the entire GI tract from the mouth to the anus where as UC is limited to the colon/rectom.

They both include extraintestinal manifestations with skin, joints, eyes, ect.

My bum is broken....there's a big crack down the middle of it!  LOL  :)

Elite Member

Date Joined May 2003
Total Posts : 30999
   Posted 12/20/2007 10:42 PM (GMT -6)   
UC affects the mucosal and for some with deeper ulcerations..the submucosal layer.

UC starts at the rectum continually spreads upward.

There's a form of UC that involves the rectum and the cecum....with the descending/transverse/ascending being clear.

There's a form of CD that affects the perianal area that causes inflammation, abscesses and fistulas...called fistulising Crohns's.

PLEASE....are you asking regarding your daughter's pathology report? ... if so, are you up for sharing?

*Heather*Status:mini flare June 23* 6asacol daily+ Salofalk (tapered every 4th night)
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 2 (Natural Factors Protec) + 1 (Primadophilus Reuteri) at bedtime
~Natural Factors Multi Digestive Enzymes with supper
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

New Member

Date Joined Sep 2003
Total Posts : 12
   Posted 12/21/2007 10:12 PM (GMT -6)   
Quote from British Gastro Journal-
"Epithelioid granulomas is one of the best histological criterion for distinguishing Crohn’s disease (CD) from other inflammatory bowel diseases"
Gut 2005;54:215-222
© 2005 by BMJ Publishing Group Ltd & British Society of Gastroenterology


Anti-Saccaromyces cerevisiae antibodies (ASCA) seem to be associated with Crohn's disease (CD), while anti-neutrophil cytoplasm antibodies (p-ANCA) seem to be a recognised marker for ulcerative colitis (UC).

PMID: 12050913 [PubMed - indexed for MEDLINE]

check this out with your gastro
Merry Christmas to all, Lulu xxx
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