Humira still is not approved for use in UC by the FDA, so many insurance companies will not cover it. And some GI's do not think it's ethically right to prescribe it, yet. Also, I think Remicade & Humira are pretty much the same thing (both biologics, Remi being chimeric, Humira being monoclonal) so one isn't necessarily any better than the other. I think if you develop antibodies to Remicade, Humira may work for you initially, as it's "all human", so to speak. I think I'd prefer getting the med infused by someone else, than myself giving the injections. Although if Remicade stops working for me, you bet I'll fight to try Humira!