potential solution for PVCs

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New Member

Date Joined Jan 2015
Total Posts : 1
   Posted 1/25/2015 5:03 PM (GMT -6)   
I've been a long-time lurker around here, but never posted. I've been struggling with PVCs for awhile, with my last holter showing over 10,000 in a day. I bounced between doctors for awhile with no real solution other than some beta blockers that didn't work. A few months ago, I visited a local clinic for an unrelated issue, and saw a doctor who was an older gentleman that I hadn't met before. I mentioned my PVC issue, and his response was surprising. He told me "ah, that's easy to solve" -- and he prescribed me two medications that he said would essentially have a good anti-arrhythmic effect but without the major issues associated with the actual heavy-duty anti-arrhythmic drugs.

The first was an older beta blocker called Acebutolol (200 mg, brand: Sectral) that he said isn't really used much anymore for blood pressure, but does have a fairly good effect on ventricular (but not other types) pre-mature contractions. The other drug was a low dose of Nortriptyline (50 mg), which is a very old style anti-depressant that apparently also has some anti-arrhythmic effects. So armed with both, I gave it a try and lo and behold... within just a few weeks, my PVCs have completely vanished. And I don't just mean reduced... vanished, poof... gone. The side effect profile was pretty minimal.

Obviously though, this is just my experience... your mileage may vary. But for those really suffering from this, it's worth investigating. It may work, it may not.

Regular Member

Date Joined Jan 2014
Total Posts : 394
   Posted 1/31/2015 6:57 PM (GMT -6)   
Congratulations. I saw an Electrophysiologist and I asked for Acebutolol, he was enthusiastic about it. It's a special class of Beta Blocker, having ISA, or Intrinsic Sympathomimetic Activity, a fancy way of saying that it slows your heart down while not slowing it as much as other Beta Blockers would, so that the effect on the heart is significant but the effect on the rate is not too much.

It's not used much anymore, you're right. But after I started taking it was the first time I had bigeminy that I could not feel, before I felt every darned PVC.

Thanks for the heads up, PVCs can be difficult to treat.
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