Caloric restriction appears to prevent primary aging in the heart
I don't think I am allowed to post the article here so there is the link, please take a look!
"People in the study averaged only six years on the diet, but their hearts looked 15 years younger. So Fontana says it's possible that the diet has a rejuvenating effect."
"He notes that most study subjects had parents, grandparents or siblings who suffered heart attacks or strokes, making it unlikely that their genetic makeup is a contributor to the unusual healthiness of their hearts. In the case of one subject, both parents and younger brother currently take medication for high blood pressure and high cholesterol. Some subjects actually took medicine for high blood pressure themselves before they started on caloric restriction. "
It's worth reading it all