I hate to tell you, but yes, it is very possible. I always had low cholesterol, and I have a 100% blocked right coronary artery, which fortunately fixed itself with collaterol veins! My husband had a heart attack, two years ago in December. His cholsterol was always in the normal range, but he did smoke. After his heart attack, he quit smoking and was put on Lipitor. His cholesterol is down to 118 - and he had another heart attack in May. The dr. blames it on low good cholesterol this time. My 100% blocked artery was found my the new 64 slice ct. coronary cat scan. You may want to check and see if your insurance would pay for that test - it is non-invasive, and gives a very, very good look at your arteries.