I have used both. For symptom management zegerid is better. It contains sodium bicarbonate - which I think is the main difference. This is basically baking soda. For me, zegerid caused horrific bubbling stomach with gas. Drink baking soda in a glass of water and if it effects you negatively (it does for me!) zegerid may do the same thing. Everyone is different though so you should probably try it on your own.