I have been taking Nexium for some 12 - 14 years now and am 46 years old. In the past 3 years, I have been having muscle aches similar to having a constant low grade of the flu. The muscle discomfort is in my legs, my arms, my chest, and in my neck. I have had the upper endoscopies, heart catherization, and blood work. All of these come back normal for my age, but I do have GERD and spasms sometimes of the esophagus. What I am asking is that does anyone know of any side affects of Nexium (PPIs) that could be causing the muscle soreness. I have heard that patients on Nexium have a problem absorbing Iron and should take supplements. I also have heard to take the Iron several hours prior to taking the Nexium. Has anyone had similar symptoms and can offer some advice or help. I don't like feeling like this. I seen every doctor in the areas of interest, but not have ever considered the side effects of the Nexium as part of the potential problem. HELP!!!!