Omeprazole (Zegerid) and St. John's Wort

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New Member

Date Joined May 2008
Total Posts : 4
   Posted 5/7/2008 10:14 AM (GMT -6)   
Hey all,
I'm new to this forum.  Nice to meet you.
I am a sufferer of GERD and am currently medicated with the PPI Zegerid powder form (40mg Prilosec, 1125mg Sodium Bicarbonate) - instant acid relief on contact via the bicarbonate compound
I have also been suffering a mild - moderate depression for the past year or so and it has gotten much worse in the recent months.
I've read different things on the effects on St. John's Wort's interactions with Omeprazole based reflux perscriptions.  I've read that it MAY reduce the effects of Omeprazole, It GREATLY reduces the effects, and it DOES NOT reduce the effects of Omeprazole.
I am wondering if anyone here suffers from Depression and GERD, and takes an Omeprazole PPI and is also on St. John's Wort?
Any help is appreciated.

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 5/8/2008 7:10 AM (GMT -6)   
I have taken both in the past at the same time. It didn't affect my Prilosec any but then again, my acid reflux is considered mild compared to many here. Have you tried any anti-depressants prescribed by your doctor yet?
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Veteran Member

Date Joined Jun 2007
Total Posts : 1345
   Posted 5/9/2008 4:07 PM (GMT -6)   
Hi there Krimzen...welcome aboard to is nice to meet you as well!

I too wonder the same thing that Sherry is wondering, have you tried any anti depressants prescribed by your doctor yet? Are you visiting with a pdoc, or just a family doc?

If you could provide a little more information, that would be great.

I do look forward to hearing from you again.

Wishing you all the best.
 GERD Forum Moderator
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 Diagnosed with Generalized Anxiety Disorder (GAD) and Panic Attacks.
 Clickable Link that may be of interest to I find I often like to check drug interactions...Drug Interactions

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