Calumet, I have been taking it for well over a year, and now I switch between their Haldi green tea and berry flavors. I believe its the way they formulate their drink that gives the biggest benefit, and not any one ingredient. I have over 1 year old protonix sitting in my cabinet at home, and I love the literature out there that shows that curcumin, and you would think especially in this drink form, helps to decrease cancers in the whole GI tract, from the mouth, espophagus and on down. Besides the pain of my GERD, that was the main reason for taking it, because I also have U.C. 4 Bucks is pretty steep, hopefully you can get it cheaper in the future. Good luck.