I would like to add one thing. PPI's worked perfectly well for me UNTIL I tried to quit them cold turkey. For some reason when I went back on them they were never the same. In fact, just prior to my recently (12 days ago) quitting them, I was suffering from mild heartburn all day every day when in fact that is something that I never had before I started on them. I was afraid that I had developed some secondary problem, and I think that was my main motivating factor to stop.
The heartburn I was experiencing STOPPED within 48 hours of quitting nexium. In my opinion, the Nexium had lost its effectiveness to the point where it was giving me mild rebound WHILE I was on it. That sounds quite ironic! I quickly figured that if I was getting mild rebound on 40mg's then obviously I need 80 or 120 to make it go away. Wait a minute!
Whenever I read on these forums about people who have heartburn while on Nexium etc..., I can't help but think that they have it because the drug has lost its effectiveness on them. But, it is hard to counsel someone with Barettes etc... to quit, when that is exactly what they should NOT be doing, at least not without the supervision of a specialist.
My big question is, how many of us PPI addicts are on the drug for the wrong reasons? Doctors can be so quick to prescribe it.
If any of you reading this have tested negative for reflux and have had upper gastroscopies that showed no damage, you owe it to yourself to try and get to the bottom of what is likely only chronic indigestion. I have no doubt about the beneficial effects of Nexium etc... but NOT for every single indigester like you or me. If we can fix our problems through diet etc... isn't that a price worth paying?