I'm on protonix 40mg twice a day still to protect my stomach from the ravages of prednosone and antibiotics. I have an extremely sensitive stomach that shuts down when assaulted, so I think it's a good plan. (I'm on Day 9, and have taken them since Day 5.)
I'm swallowing protonix whole...they're a good shape, and smooth...quite small. They seem to be going in, but who knows? I cut my prednosone into quarters (I had him give me smaller dose tablets and take 2)...then I swallow them with water one quarter at a time. I have always taken some giant vitamins, calcium, vitamin C complex, etc...I can't even imagine ever taking pills that size again...I don't know if I'd ever have the confidence.
I quit taking the pain meds, mainly because they were huge and nasty. Liquid Tylenol was so much easier.
Good luck swallowing!