Has anyone experienced anything similar to this? If so, please let me know if you went back to your doctor and what he did for you. I've been on Prilosec for over 10 years due to persistant heartburn from Gerd . It was the result of a hiatal hernia. For much of this time I was doing fine. about a week ago, I started having mild heartburn and excessive belching that would get me awake at night, despite using my Prilosec faithfully. I've been taking 20 mg of Prilosec faithfully every morning before breakfast. It appears as if the Prilosec might be loosing some of it's effectiveness. Any input would be appreciated.