link to PPIs and Cancer

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Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 10/13/2009 9:08 PM (GMT -6)   
Hi all,

I donĀ“t want to scare anyone, but just want to put this up here so that anyone interested or that is taking PPIs can take a look. Maybe not worth freaking out for, but certainly worth a quick read.

Regular Member

Date Joined Sep 2009
Total Posts : 59
   Posted 10/15/2009 4:50 PM (GMT -6)   
hey acireflux man, did you do the surgery..???

i know the ppis are not good, i know...i have my 6th sense telling me that everyday:(

Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 10/15/2009 9:06 PM (GMT -6)   
hi jules,
good to hear from you, ive read some of your posts and we are both in a similar predicament...relatively young and struggling with gerd.
my gi and surgeon both want me on pills for life and have ruled out the surgery for the time being, so I am trying to go on natural alternatives and control it...
Ive been off Nexium for a week (I had to go off it to do the 24 hour PH, which was finished today), but am not going to start up right away. I wanted to go off gradually but since I have been off it an entire week I am going to go ahead and see if I can get off Nexium...
I have pain various times during the day but quick and not really pain, just discomfort. I am HOPING that I am having the acid rebound people talk about after getting off a PPI *I really cant tell if I am having it or not*...I am just going to try to manage without the nexium for now and see if in a month or so my stomach acidity gets back to normal and I can control it naturally, but who knows. I am hoping...
If not Ill probably go back on nexium for the next few years before vying for the surgery again...
How have you been? What are your thoughts on your GERD as it is right now?

New Member

Date Joined Sep 2009
Total Posts : 16
   Posted 10/18/2009 10:38 AM (GMT -6)   
The article is very alarming since I take Pantoprazole on a regular basis :(( Not taking it scares me more because I'm afraid of esophageal cancer caused by acids in my esophagus. I've already had a bout of hematemesis (vomiting of blood) due to tearing in my esophagus and I don't want a repeat performance :((

Please share what alternative methods work for you. I started trying Aloe Vera but it gives me diarrhea so I stopped after taking it for only 3 days. I'll take it up again and see if I can tolerate it better. A friend who also has GERD told me to try activated charcoal pills since it worked wonders for him.

My husband's a surgeon and does not recommend the fundo for me. He likes the LINX though so I hope the FDA will have it approved soon. Thanks for sharing the article.

New Member

Date Joined Oct 2009
Total Posts : 17
   Posted 10/20/2009 1:05 AM (GMT -6)   
Somebody said...
I have pain various times during the day but quick and not really pain, just discomfort. I am HOPING that I am having the acid rebound people talk about after getting off a PPI
Ok, I am at the end of this one right now, so here is what I have found, maybe it will help you.  I was taking Prevacid and Aciphex for about 3 weeks, and had side-effects, so I went off them.  I experienced worse heartburn than I had EVER had before almost immediately, along with a "slow burn" feeling in my stomach that was always present.   I took liquid antacids and Zantac, but they barely controlled it at all.  I was panicked because the PPIs seemed to have made the GERD go ballistic.  However, the good news it that after about 4-5 days, I cut the Zantac down to 1/2 pill per day (not much at all) and things were not perfect, but I wasn't in constant pain.  The next few days the "slow burn" continued on and off, and right now I'm off all pills, but still using Tums and Mylanta once or twice a day to calm things.   Thus, it IS recovering slowly, but I'm scared of how much the PPIs threw my system off.
The reason I bailed on the PPIs is (1) they were making me sick and nonfunctional and (2) I did some reading on gastrin and cancers, and gastrin is associated with higher cancer risk in many many studies (while the PPI studies seem to claim that gastrin does nothing harmful, which I find doubtful).  PPIs throw gastrin through the roof, and leave it there while you're on them.
I almost feel like I need to be my own doctor now, since the PPI game looks to me like a sure way to end up ill for life, as long as it lasts.  I'm not a medical expert of any kind, but elevated gastrin levels combined with ghrelin hormones raised causing muscle loss and fat gain is basically a path to ruin.  I need to LOSE weight, not gain it.
Anyway, best of luck, I think you can get off the PPIs, but it takes a fairly long time for your stomach to do any kind of calm-down or reset.  I'm not sure where to go from here, aside from to start monitoring my gastrin levels.  We seem to be living in the Dark Ages when it comes to gastro-intestinal medicine.  I have no idea why that is the case, but it is more and more clear that doctors will prescribe PPIs until the cows come home because they don't know what else to do.

New Member

Date Joined Aug 2014
Total Posts : 2
   Posted 8/7/2014 10:13 AM (GMT -6)   
Loved your last line AcidStorm >>> "PPIs until the cows come home because they don't know what else to do" is this not always the case? and a great cause for concern.
Just diagnosed with Barrett's of the esophagus and before my scope and being put on Pantoprazole I felt just fine.
I had a good appetite could eat anything especially pepper rings that I loved with my meals.But since all the diagnoses and pill pushing I feel like crap and that being said the answer both my Family Doctor and gastro specialist said after I told both of them about my pain since the test and pill they both claim that going on an anti depressant would help me now with the pain.So now from someone who never took medications is now being pushed to take them.And like a roller coaster if one makes you ill fix it with another one seems to always be the case.
My fear is this when I speak to both of then they claim that if I stop taking Pantoprazole in short my chances of dying of this disease is greater!!! so that's a pretty big risk when someone tells you your going to die with out it right.
So my question Is how much truth is in this?

Veteran Member

Date Joined Mar 2012
Total Posts : 1110
   Posted 8/7/2014 12:06 PM (GMT -6)   
Are you able to take an I2 Blocker?
GERD Moderator; Diagnosed GERD, possible IBS; Gluten free since 2012; low lactose since 2012
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