Well, they are supposed to be similar, but most people find that certain ones work and others don't or they stop working over time. I never got any relief from Prilosec, butPrevacid, Achiphex, and Nexium did work. I had to go to a higher dosage on the Prevacid a couple times though. I also found that the prevacid solutabs worked better for me, but the taste isn't the greatest. IT's not bad, but not great either.