Antihistamine to help with GERD

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Regular Member

Date Joined Nov 2006
Total Posts : 289
   Posted 4/5/2010 10:52 PM (GMT -6)   
Have you ever used antihistamine to help with GERD?  Please state what kind you have used.

Veteran Member

Date Joined Oct 2009
Total Posts : 5029
   Posted 4/6/2010 12:22 AM (GMT -6)   
Why would you take an antihistamine?  Do you have reason to suspect something you are eating is an allergen?  GERD triggers can be food sensitivities/allergies.
I have a large list of food triggers that start my stomach refluxing.  (Actually that was in the past because I had to have surgery following an accident to pull my stomach down out of my chest.  I was given a partial wrap, but my stomach still reacts with spasma which trigger tachycardia when I eat something with sulfites in it.)

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Date Joined Feb 2009
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   Posted 4/6/2010 5:47 AM (GMT -6)   
Hi...I've taken antihistamines pretty much continually as I've suffered with GERD and have not noticed any effect. I have lots of allergies, and the antihistamines have helped them, but I haven't noticed any affect on my GERD symptoms over that time.
Good luck finding answers!

Regular Member

Date Joined Nov 2006
Total Posts : 289
   Posted 4/6/2010 11:08 PM (GMT -6)   
The reason I'm asking about antihistamines is because I read the below show article and my sister who was diagnosed with GERD finds much relief when she takes Zyrtec.  I know it's weird.


Antihistamines are also used to treat acid reflux. Stomach walls produce histamine. Histamine accelerates acid production by binding specific receptors present on acid producing cells of stomach. Antihistamine drugs bind to these receptors and block histamine binding that in turn reduces the acid production. Ranitidine, Famotidine, Cimetidine and Nizatidine are commonly used antihistamines or histamine antagonists. They are available without prescription as over-the-counter (OTC) but the dose of OTC is lower than those available by prescription. Antihistamine drugs are taken 30 minutes earlier than meal. This will make antihistamine available in higher concentration when stomach is actively producing acids to digest food. Antihistamine gives fast relief from primary heartburn and inflammation of esophagus.

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Date Joined Feb 2009
Total Posts : 7188
   Posted 4/7/2010 6:29 AM (GMT -6)   
I never knew that Zantac (Ranitidine) was an antihistimine. I did know that histamine production was part of the GERD issue. Interesting. I do take antihistimines fairly regularly (daily during the growing season) and have had GERD symptoms in spite of them. I'd be interested in your results if you try the antihistamine route.
Best wishes!

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 4/7/2010 10:09 AM (GMT -6)   
H2 blockers, also called H2-receptor antagonists, are medicines that reduce the amount of acid the stomach produces by blocking one important producer of acid: histamine2.

Histamine2, a common chemical in the body, signals the stomach to make acid. H2 Blockers oppose histamine’s action and reduce the amount of acid the stomach produces. This type of medication is used to treat conditions in which the stomach produces too much acid, such as gastroesophageal reflux disease. They also have been prescribed for the treatment of peptic ulcer symptoms.

Drugs that work by this mechanism in the United States are Zantac (ranitidine), Pepcid (famotidine), Tagamet (cimetidine) and Axid (nizatidine).

Antihistamines are classified as H1 blockers and H2 blockers, depending on the type of receptors (on the surface of cells) that they act on. H1 receptors are associated with human tissue involving capillaries, and H2 receptors predominate in the lining of the stomach.

The H1 blockers are the meds generally used for allergic reactions.

Hope this helps with your question.

Take care,


Pat Tall
Veteran Member

Date Joined Aug 2012
Total Posts : 950
   Posted 5/14/2014 1:00 PM (GMT -6)   
Hi all-- I know this is an older forum, but has anyone tried the DAO supplements that suppress histamine production 'naturally' without medicine. If so-- any success-- what brand name. It is pricey and the web has a lot of info regarding 'histamine intolerances' and the effect on acid reflux. At the present time we are avoiding the high histamine foods and foods that activate histamine itself to help 'possibly' bring the body levels down. Any thoughts. Thanks. Pat

Veteran Member

Date Joined Apr 2011
Total Posts : 1604
   Posted 5/15/2014 3:24 PM (GMT -6)   
I agree with Denise - I take Zantac 150 mg twice daily for GERD and often take Telfast for my allergies. I've never noticed any extra benefit when on both medications, either to my GERD or my allergy symptoms. If anything I get a bit dizzy when taking both together!


Regular Member

Date Joined Apr 2014
Total Posts : 122
   Posted 5/16/2014 8:08 AM (GMT -6)   
Could antihistamines help my coughing? I observed i always cough when im so full or if when im so hungry.

New Member

Date Joined Feb 2018
Total Posts : 1
   Posted 2/22/2018 10:45 AM (GMT -6)   
I have had acid reflux (GERD) for many years. In recent years it became much worse causing me constant pain and now even have been diagnosed with Berets Esophagus. I was put on higher and higher doses of Omeprazole and it is now seeming to be lessoning the symptoms and not always in pain but slight discomfort most of the time. I recently caught influenza B and was put on an antiviral (Tamiflu) and also was taking a cold medicine drink that the active ingredient was diphenhydramine (Active ingredient in Benadryl) and I noticed over the five days I was taking it I had no GERD symptoms or pain. Stopped taking the cold medicine as I am over my Flu and my pain has returned. So yesterday evening as an experiment I took a small dose of the cold medicine and to my surprise today I am pain free. I even forgot to take my Omeprazole this morning?

Regular Member

Date Joined Jan 2018
Total Posts : 39
   Posted 2/22/2018 8:17 PM (GMT -6)   
cnstntsrow, my GI specialist had worked with my ENT specialist to also recommend antihistamines. Besides allergies for which I needed histamines anyway, we found taking the antihistamine helped with my GERD induced post nasal drip and coughing episodes (mostly from regurgitating acid and fluids - sometimes coming up my nose too). They did tell me once I have surgery for both (the ENT part that was damaged from acid and also the GI aspect fixed via Toupet), I wouldn't need acid blockers or antihistamines. I have not needed any drugs since 2015 when I had my Toupet surgery. They fixed the nasal damage surgically before that in 2013 but I stayed on the antihistamines at a lower dose. However, completely stopped all medication after I came to in 2015 right after the Toupet surgery). I hope this helps you.

Post Edited (reena20) : 2/22/2018 6:25:38 PM (GMT-7)

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