Hello and welcome to HealingWell,
I am on a PPI so I have not experienced this rebound effect. I have read information that states this rebound is theorized to the result of an overproduction of the stomach acid-stimulating hormone gastrin in response to PPI-related acid suppression.
When the medication is stopped, the extra gastrin in the blood signals the stomach to work overtime to produce acid. When gastrin levels return to normal, acid secretion slows. The phenomenon, known medically as rebound acid hypersecretion. Reference: Christina Reimer, MD, of Copenhagen University.
~~Kitt~~Moderator: Anxiety/Panic, Osteoarthritis, GERD/Heartburn and Heart/Cardiovascular Disease. www.healingwell.com"If you can't change the world, change your world"