New here and would so appreciate any feedback on possible acid rebound...

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New Member

Date Joined Oct 2010
Total Posts : 1
   Posted 10/31/2010 9:36 AM (GMT -6)   
Hi friends,
Thanks for taking the time to listen to a newbie.

My journey started about a year and a half-ago. I had intermittent but fairly frequent heartburn that didn't resolve after pregnancy and the beginning of swallowing problems (feeling of food stuck in my chest). I had a normal barium swallow, then a few months later an endoscopy that showed a small hiatal hernia, some evidence of reflux and possible eosinophilic esophagitis.

I started on lansoprazole in January and after 2 months, switched to dexilant. My swallowing problems didn't go away, so doctor gave flovent to treat the eosinophilic esophagitis. I stayed on Dexilant the whole time. With the flovent, I improved a lot (not 100%, but doing well overall).

I finished the course of flovent and then, very slowly, over the summer, a feeling of very mild, but constant heartburn started to return. It would start with the first sip of water I took in the morning (sometimes even before) and usually last all day. (I still am on dexilant all through this.)

My doctor did another endoscopy 4 weeks ago and showed that my whole esophagus was inflamed with a very high eosinophil count. I went back on the flovent for the eosinophilic esophagitis and he wanted me to go off dexilant, so I did that and 2 days later, was miserable with horrible heartburn - worse than it ever was to begin with. He then told me to take pepcid instead before every meal and before bed - did that for a week. That seemed to help a lot. After that week, he told me to step down to 2 pepcids a day. I was ok with that for about a week and a half.

Then, my stomach revolted. For the last week or so, I have been dealing with a continuously angry, upset, miserable stomach. This basically came completely out of the blue. Also, I have intermittent feelings of fullness in my chest - like it is filled with gas and it feels like someone has their hands squeezing around my neck. All reflux symptoms (with the exception of actual heartburn) 24/7.

My doctor told me to go back on the dexilant for a week to see if that helps in case I am suffering from acid rebound. Today is day 5 of return to dexilant and I am still very sick to my stomach and am feeling that this is just never going to end.

I was wondering if anyone thought I might be experiencing acid rebound now? My doctor was quite dismissive of acid rebound until I called him up last week telling him how sick I felt. It seems like I was stepping down off the medications ok for a few weeks before everything hit the fan and I thought acid rebound would have showed up sooner.

I'm just confused and tired of feeling this way. I would appreciate any suggestions or thoughts from any of you more experienced with this than me.

Thanks so much!

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 10/31/2010 10:05 AM (GMT -6)   
Hello and welcome to HealingWell,
I am on a PPI so I have not experienced this rebound effect.  I have read information that states this rebound is theorized to the result of an overproduction of the stomach acid-stimulating hormone gastrin in response to PPI-related acid suppression.

When the medication is stopped, the extra gastrin in the blood signals the stomach to work overtime to produce acid. When gastrin levels return to normal, acid secretion slows.  The phenomenon, known medically as rebound acid hypersecretion. Reference: Christina Reimer, MD, of Copenhagen University.

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