radical changes, prilosec, etc...why is it not working?

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Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 12/28/2010 12:14 PM (GMT -6)   
I am still suffering heartburn throughout the day (though much less than before), even though I am on 2 prilosec's per day, as well as eating like a saint according to the Alkaline diet.

In a given day I am eating sweet potatoes, quinoa/millet, cereal w/ almond mik + bananas + blueberries, watermelon (when I feel heartburn coming on), greens (spinach, green beans, broccoli and cauliflower). I don't break that routine, and really all that I am eating falls under alkaline.

I am doing my best and make absolutely no exceptions (have been eating like this for about 5 days). Does this all mean that I am the ideal candidate for surgery? I can't believe that 2 prilosecs/day don't work for me - in the past, 1 per day was more than enough to let me eat anything I wanted without any symptoms.

Even 5 months ago I was on 1 ranitidine per day, which I had to stop due to side-effects. BUT just one ranitidine took away my symptoms completely.

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 12/28/2010 1:43 PM (GMT -6)   
If your LES is weak and acid is getting in the esophagus and medicine doesn't help then, yes, you need the surgery.

Regular Member

Date Joined Nov 2010
Total Posts : 60
   Posted 1/13/2011 12:40 PM (GMT -6)   
When do you take your Prilosec (ie omeprazole) ?   
I was shocked when I was put on this medication, and I took it after lunch, to find out afterwards I had to take it first thing in the morning on an empty stomach!

Regular Member

Date Joined Dec 2010
Total Posts : 42
   Posted 1/13/2011 4:04 PM (GMT -6)   
I took it in the morning on an empty stomach and it didn't work when I went to lay down and sleep. Had heartburn in the morning when I first woke up too. Now I take it at night before going to bed and don't have the heartburn.

Regular Member

Date Joined Mar 2004
Total Posts : 302
   Posted 1/27/2011 4:47 AM (GMT -6)   
Heartburn in the morning when you first wake up. Sounds like acid is getting into your esophagus while you're sleeping on a flat mattress. My cure for that was sleeping on a foam wedge that raises my torso about 7 inches.

It's also possible that your current medication just isn't working for you. Not all PPIs (proton pump inhibitors) are alike. I've been on them all and only Nexium 40mg 2xday works for me. If you're not already doing this, try taking one pill when you wake up and the second one about 7-8 hours later. Always on an empty stomach, at least one hour before eating.

You eat fruit? If I even take a bite of fresh fruit my acid reflux kicks in big time, even with Nexium. Fruit is very acidic. I've also found that tomatoes are my worst enemy. Don't jump into surgery until you've tried all the medications. Surgery isn't always the answer and it can sometimes lead to bigger problems.
If I didn't have humor to help fight the disease, I'd spend the rest of my life in tears.

New Member

Date Joined Dec 2010
Total Posts : 16
   Posted 1/27/2011 12:25 PM (GMT -6)   
Good advice from Linlou.

I have tried nearly all the PPIs out there.... and could not find any that work for me... I have finally settled on Zegrid in the morning and prescription strength Pepcid at night and I still use liquid Gaviscon periodically though out the day. You might aslo watch what you drink... cola drinks, coffee and tea are all really bad on the acid front.... and stress is a big factor in acid production, so try to relax and not worry so much; enjoy life to the fullest;) This site is wonderful full of compassionate people who have a lot wisdom and have walked in your shoes... Keep your your chin up:)

Best wishes to you:)

Veteran Member

Date Joined Oct 2009
Total Posts : 5029
   Posted 1/27/2011 1:00 PM (GMT -6)   
As some have already noted, how you take your PPI really does make a difference. I have found, and read, that you have to take it half an hour to an hour before eating, and then you do have to eat something! I take it with my morning coffee, eat breakfast half an hour to an hour later.

I also agree that the brand of PPI makes a difference. Some simply do not last very long. For me Nexium is the only one I found acceptable. Even that one doesn't last 24 hours for me.

Acidrefluxman - some of the foods you are eating can cause stomach upset: bananas for one for sure. I do well with avoiding bread, but rice seems to not cause a problem, or gas.

Seriously, please see a gastro doc. There is no way we, mere patients, on the forum can diagnose whether you need surgery.
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